Methods in protein design Volume 523 /
| Other Authors: | Keating, Amy E., ScienceDirect (Online service) |
|---|---|
| Format: | eBook |
| Language: | English |
| Published: |
San Diego, Calif. :
Academic,
2013.
|
| Physical Description: |
1 online resource (xviii, 464 pages) : illustrations. |
| Series: |
Methods in enzymology ;
volume 523. |
| Subjects: |
| Item Description: |
Includes bibliographical references and indexes. Computational design of novel protein binders and experimental affinity maturation -- Mining tertiary structural motifs for assessment of designability -- Computational methods for controlling binding specificity -- Flexible backbone sampling methods to model and design protein alternative conformations -- Osprey: protein design with ensembles, flexibility, and provable algorithms -- Scientific benchmarks for guiding macromolecular energy function improvement -- Molecular dynamics simulations for the ranking, evaluation, and refinement of computationally designed proteins -- Multistate protein design using CLEVER and CLASSY -- Using analyses of amino acid coevolution to understand protein structure and function -- Evolution-based design of proteins -- Protein engineering and stabilization from sequence statistics: variation and covariation analysis -- Enzyme engineering by targeted libraries -- Generation of high-performance binding proteins for pepetide motifs by affinity clamping -- Engineering fibronectin-based binding proteins by yeast surface display -- Engineering and analysis of peptide-recognition domain specificities by phage display and deep sequencing -- Efficient sampling of SCHEMA chimera families to identify useful sequence elements -- Protein switch engineering by domain insertion -- Design of chimeric proteins by combination of subdomain-sized fragments -- [alpha]-helix mimicry with [alpha/beta]-peptides. |
|---|---|
| Physical Description: |
1 online resource (xviii, 464 pages) : illustrations. |
| Bibliography: |
Includes bibliographical references and indexes. |
| ISBN: |
9780123946294 0123946298 |
| ISSN: |
0076-6879 ; |