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PET and SPECT of neurobiological systems

Other Authors: Dierckx, Rudi A. J. O., Otte, Andreas P., 1967-, Vries, Erik F. J. de., Waarde, Aren van., Lammertsma, Adriaan A., SpringerLink (Online service)
Format: eBook
Language: English
Published: Cham, Switzerland : Springer, [2021]
Physical Description: 1 online resource.
Edition: 2nd ed.
Subjects:
Tomography, Emission.
Radioisotope scanning.
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245 0 0 |a PET and SPECT of neurobiological systems /  |c Rudi A.J.O. Dierckx, Andreas Otte, Erik F.J. de Vries, Aren van Waarde, editors ; Adriaan A. Lammertsma, guest editor. 
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505 0 |a Intro -- Foreword -- Preface -- Contents -- Part I: Basics -- 1: Animal Models for Brain Research -- 1.1 Introduction to Animal Modelling for Human Brain Disease -- 1.1.1 Relevance of Animal Models -- 1.1.2 Validity of Animal Models -- 1.1.2.1 Face Validity -- 1.1.2.2 Construct Validity -- 1.1.2.3 Aetiological Validity -- 1.1.2.4 Predictive Validity -- 1.1.3 Homology, Analogy and Isomorphism -- 1.1.4 Generalisation and Extrapolation -- 1.2 Animal Models of Psychiatric Disorders -- 1.2.1 The Endophenotype Concept in Psychiatry -- 1.2.2 Approaches to Modelling Psychiatric Disease. 
505 8 |a 1.2.2.1 Behavioural Approach -- 1.2.2.2 Pharmacological Models -- 1.2.2.3 Genetic Models -- 1.2.3 Animal Models of Schizophrenia -- 1.2.3.1 Aetiology and Symptomatology of Schizophrenia -- 1.2.3.2 Validating Animal Models of Schizophrenia -- Electrophysiological Endophenotypes -- Cognitive Endophenotypes -- Locomotor Activity -- Sensory Discrimination -- Negative Symptoms -- 1.2.3.3 Neurodevelopmental Schizophrenia Models -- 1.2.3.4 Drug-Induced Schizophrenia Models -- Psychostimulant Models -- Hallucinogen Models -- 1.2.3.5 Lesion-Induced Schizophrenia Models. 
505 8 |a 1.2.3.6 Genetic Schizophrenia Models -- Inbred and Selectively Bred Rodent Strains -- Genetically Modified Models -- 1.3 Animal Models of Neurological Disorders -- 1.3.1 Approaches to Modelling Neurological Disorders -- 1.3.2 Animal Models of Alzheimer's Disease -- 1.3.2.1 Aetiology and Symptomatology of Alzheimer's Disease -- 1.3.2.2 Validating Animal Models of Alzheimer's Disease -- Cognitive Symptoms -- BPSD-Related Symptoms -- Pathological Alterations -- Neurochemical Alterations -- 1.3.2.3 Spontaneous and Selectively Bred Alzheimer's Disease Models. 
505 8 |a 2.1.3.1 Volume of Distribution -- 2.1.3.2 Input Function -- 2.1.3.3 One-Tissue Compartment Model -- 2.1.3.4 Two-Tissue Compartment Model -- 2.1.3.5 Logan Plot -- 2.1.4 Reference Tissue Models -- 2.1.4.1 Binding Potential -- 2.1.4.2 Simplified Reference Tissue Model -- 2.1.5 Receptor Occupancy and Displacement -- 2.1.6 Semiquantitative Approach -- 2.1.7 Radioligands -- 2.2 PET Motion Correction: State of the Art -- 2.2.1 The Need for Awake PET: Anesthesia, Stress, and Its Impact on Small Animal PET -- 2.2.2 Motion Correction in PET Reconstruction. 
500 |a 2.2.3 Head Motion Tracking for Awake Small Animal PET. 
650 0 |a Tomography, Emission. 
650 0 |a Radioisotope scanning. 
650 2 |a Positron-Emission Tomography. 
650 2 |a Tomography, Emission-Computed. 
650 2 |a Radionuclide Imaging. 
650 6 |a Tomographie par émission. 
650 6 |a Scintigraphie. 
650 7 |a Tomography, Emission.  |2 fast. 
650 7 |a Radioisotope scanning.  |2 fast. 
700 1 |a Dierckx, Rudi A. J. O. 
700 1 |a Otte, Andreas P.,  |d 1967-  |1 https://id.oclc.org/worldcat/entity/E39PBJqKdkymR7D3pDpxDrdmh3. 
700 1 |a Vries, Erik F. J. de. 
700 1 |a Waarde, Aren van. 
700 1 |a Lammertsma, Adriaan A. 
710 2 |a SpringerLink (Online service) 
776 0 8 |i Print version:  |a Dierckx, Rudi A.J.O.  |t PET and SPECT of Neurobiological Systems.  |d Cham : Springer International Publishing AG, ©2020  |z 9783030531751. 
880 8 |6 505-00/(S  |a Pharmacological, Chemical and Lesion-Induced Rodent Models of Alzheimer's Disease -- 1.3.2.4 Amyloid-Ý Infusion Rodent Models of Alzheimer's Disease -- 1.3.2.5 Genetically Modified Alzheimer's Disease Mouse Models -- 1.4 Imaging in Rodent Models of Brain Disease -- 1.4.1 Imaging in Schizophrenia -- 1.4.2 Imaging in AD -- 1.5 Conclusion -- References -- 2: The Use of Small Animal Molecular Imaging (oPET) Exemplified in a Neurobiological Pathology -- 2.1 Introduction on oPET -- 2.1.1 Physics and Principle of PET -- 2.1.2 Pharmacokinetic Modelling -- 2.1.3 Compartment Models. 
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