PET and SPECT of neurobiological systems
| Other Authors: | Dierckx, Rudi A. J. O., Otte, Andreas P., 1967-, Vries, Erik F. J. de., Waarde, Aren van., Lammertsma, Adriaan A., SpringerLink (Online service) |
|---|---|
| Format: | eBook |
| Language: | English |
| Published: |
Cham, Switzerland :
Springer,
[2021]
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| Physical Description: |
1 online resource. |
| Edition: | 2nd ed. |
| Subjects: |
| Item Description: |
Intro -- Foreword -- Preface -- Contents -- Part I: Basics -- 1: Animal Models for Brain Research -- 1.1 Introduction to Animal Modelling for Human Brain Disease -- 1.1.1 Relevance of Animal Models -- 1.1.2 Validity of Animal Models -- 1.1.2.1 Face Validity -- 1.1.2.2 Construct Validity -- 1.1.2.3 Aetiological Validity -- 1.1.2.4 Predictive Validity -- 1.1.3 Homology, Analogy and Isomorphism -- 1.1.4 Generalisation and Extrapolation -- 1.2 Animal Models of Psychiatric Disorders -- 1.2.1 The Endophenotype Concept in Psychiatry -- 1.2.2 Approaches to Modelling Psychiatric Disease. 1.2.2.1 Behavioural Approach -- 1.2.2.2 Pharmacological Models -- 1.2.2.3 Genetic Models -- 1.2.3 Animal Models of Schizophrenia -- 1.2.3.1 Aetiology and Symptomatology of Schizophrenia -- 1.2.3.2 Validating Animal Models of Schizophrenia -- Electrophysiological Endophenotypes -- Cognitive Endophenotypes -- Locomotor Activity -- Sensory Discrimination -- Negative Symptoms -- 1.2.3.3 Neurodevelopmental Schizophrenia Models -- 1.2.3.4 Drug-Induced Schizophrenia Models -- Psychostimulant Models -- Hallucinogen Models -- 1.2.3.5 Lesion-Induced Schizophrenia Models. 1.2.3.6 Genetic Schizophrenia Models -- Inbred and Selectively Bred Rodent Strains -- Genetically Modified Models -- 1.3 Animal Models of Neurological Disorders -- 1.3.1 Approaches to Modelling Neurological Disorders -- 1.3.2 Animal Models of Alzheimer's Disease -- 1.3.2.1 Aetiology and Symptomatology of Alzheimer's Disease -- 1.3.2.2 Validating Animal Models of Alzheimer's Disease -- Cognitive Symptoms -- BPSD-Related Symptoms -- Pathological Alterations -- Neurochemical Alterations -- 1.3.2.3 Spontaneous and Selectively Bred Alzheimer's Disease Models. 2.1.3.1 Volume of Distribution -- 2.1.3.2 Input Function -- 2.1.3.3 One-Tissue Compartment Model -- 2.1.3.4 Two-Tissue Compartment Model -- 2.1.3.5 Logan Plot -- 2.1.4 Reference Tissue Models -- 2.1.4.1 Binding Potential -- 2.1.4.2 Simplified Reference Tissue Model -- 2.1.5 Receptor Occupancy and Displacement -- 2.1.6 Semiquantitative Approach -- 2.1.7 Radioligands -- 2.2 PET Motion Correction: State of the Art -- 2.2.1 The Need for Awake PET: Anesthesia, Stress, and Its Impact on Small Animal PET -- 2.2.2 Motion Correction in PET Reconstruction. 2.2.3 Head Motion Tracking for Awake Small Animal PET. |
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| Physical Description: |
1 online resource. |
| ISBN: |
9783030531768 3030531767 |