Phosphoinositide 3-kinase in health and disease Volume 2 /
PI3K has become a very intense area of research, with over 2000 publications on PI3K in PubMed for 2009 alone. The expectations for a therapeutic impact of intervention with PI3K activity are high, and progress in the clinical arena is being monitored by many. However, targeted therapies almost inva...
| Other Authors: | Rommel, Christian., Vanhaesebroeck, Bart., Vogt, P. K. 1932-, SpringerLink (Online service) |
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| Format: | eBook |
| Language: | English |
| Published: |
Berlin ; Heidelberg :
Springer,
©2011.
Berlin ; Heidelberg : [2011] |
| Physical Description: |
1 online resource (x, 304 pages) : illustrations. |
| Series: |
Current topics in microbiology and immunology ;
v. 347. |
| Subjects: |
| Summary: |
PI3K has become a very intense area of research, with over 2000 publications on PI3K in PubMed for 2009 alone. The expectations for a therapeutic impact of intervention with PI3K activity are high, and progress in the clinical arena is being monitored by many. However, targeted therapies almost invariably encounter roadblocks, often exposing unresolved questions in the basic understanding of the target. |
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| Item Description: |
Includes bibliographical references and index. 880-01 Phosphoinositide 3-kinase in Health and Disease; Volume 2; Contents; Contributors; PI3K: From the Bench to the Clinic and Back; Oncogenic Mutations of PIK3CA in Human Cancers; Structural Effects of Oncogenic PI3Ka Mutations; Comparing the Roles of the p110a and p110beta Isoforms of PI3K in Signaling and Cancer; Phosphatidylinositol 3-Kinase: The Oncoprotein; AKT Signaling in Physiology and Disease; Faithfull Modeling of PTEN Loss Driven Diseases in the Mouse; PI3K as a Target for Therapy in Haematological Malignancies; Clinical Development of Phosphatidylinositol-3 Kinase Pathway Inhibitors. PI3K has become a very intense area of research, with over 2000 publications on PI3K in PubMed for 2009 alone. The expectations for a therapeutic impact of intervention with PI3K activity are high, and progress in the clinical arena is being monitored by many. However, targeted therapies almost invariably encounter roadblocks, often exposing unresolved questions in the basic understanding of the target. |
| Physical Description: |
1 online resource (x, 304 pages) : illustrations. |
| Bibliography: |
Includes bibliographical references and index. |
| ISBN: |
9783642148163 3642148166 9783642148156 3642148158 |