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20210116032204.9 |
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|a 571.8/45
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|a Gametogenesis /
|c volume editor, Paul M. Wassarman.
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|a Oxford :
|b Academic,
|c 2013.
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|a 1 online resource (336 pages).
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|b txt
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|a online resource
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|a Current topics in developmental biology.
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|a This new volume of Current Topics in Developmental Biology covers the area of gametogenesis, with contributions from an international board of authors. The chapters provide a comprehensive set of reviews covering such topics as germline stem cells, signaling modalities during oogenesis in mammals, and genomic imprinting as a parental effect established in mammalian germ cells. Covers the area of gametogenesis International board of authors Chapters provide a comprehensive set of reviews covering such topics as germline stem cells, signaling modalities during oogenesis in mammals, and genomic imprinting as a parental effect established in mammalian germ cells.
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|a Print version record.
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|a Includes bibliographical references and index.
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|a Front Cover; Gametogenesis; Copyright; Contents; Contributors; Preface; Chapter One: Cohesin in Gametogenesis; 1. Introduction; 2. Meiosis I; 3. Meiosis II; 4. Cohesin Loading and Associated Factors; 5. Role of Cohesin in Checkpoint Mechanisms; 6. Centromeres, Kinetochores, and Centrioles; 7. Errors and Age Effects in Oocytes; 8. Perspective/Questions; References; Chapter Two: Genomic Imprinting Is a Parental Effect Established in Mammalian Germ Cells; 1. Introduction; 2. Discovery of Genomic Imprinting; 3. Expression of Imprinted Genes; 4. Coregulation of the Imprinted Genes in Clusters.
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|a 5. DNA Methylation6. DNA Demethylation; 7. Cycle of DMR Methylation; 8. Establishment of the DNA Methylation Imprint; 9. Maintenance of the DNA Methylation Imprint; 10. Imprinting Control Mechanisms; 11. Igf2-H19 Imprinted Region; 12. Igf2r Imprinted Region; 13. Dlk1-Gtl2 Imprinted Region; 14. Snrpn Imprinted Region; 15. Imprinting-Related Human Diseases; 16. Macro ncRNA in Imprinting Control; 17. Imprinting in Pluripotent Stem Cells; 18. Evolution of Imprinting; 19. Conclusions; Acknowledgments; References.
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|a Chapter Three: The Identity and Fate Decision Control of Spermatogonial Stem Cells: Where Is the Point of No Return?1. Introduction; 2. Heterogeneity of Isolated Type A Spermatogonia and the SSC Population Size in the Mouse Testis; 2.1. Morphological and phenotypic heterogeneity in undifferentiated spermatogonia; 2.2. Functional detection of SSCs; 2.3. Estimating the proportion of functional SSCs in As spermatogonia; 2.4. Issues involved with spermatogonial heterogeneity; 3. Cell-Surface and Intracellular SSC Markers; 3.1. Cell-surface SSC markers; 3.2. Intracellular molecules as SSC markers.
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|a 3.3. Marker-function linkage4. Balance Between Self-Renewal and Commitment; 4.1. Cell-extrinsic factors; 4.2. Struggle between self-renewal and commitment; 4.3. Posttranscriptional mechanisms that potentially support SSC commitment; 4.4. Does the niche dictate SSC fate?: Neighboring germ cells as a niche component; 5. The Point of No Return: When and How Does SSC Commitment Start and End?; 5.1. Point of no return in the meiotic entry of yeast; 5.2. Development of nematode vulva; 5.3. Commitment process in the HSC system; 5.4. Toward identification of the point of no return in SSC commitment.
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|a 6. Concluding RemarksReferences; Chapter Four: Germline Stem Cells; 1. Spermatogonial Stem Cells; 1.1. Introduction; 1.2. The origin of SSCs; 1.3. The location, isolation, self-renewal, and pluripotency of SSCs; 1.4. Role of SSCs in spermatogenesis; 1.5. Expression of the specific genes in SSCs; 1.6. The regulatory mechanisms of SSC self-renewal, pluripotency, and spermatogenesis in mammals; 1.6.1. The key regulatory genes in SSC development; 1.6.2. Epigenetic control in SSC development; 1.6.3. Small RNAs in regulation of SSC development; 1.6.4. piRNA in regulation of SSC development.
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|a Text in English.
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|a Gametogenesis.
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|a Gametogenesis.
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|a Electronic books.
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|a Wassarman, Paul M.
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|a ScienceDirect (Online service)
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|a Current topics in developmental biology.
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|3 Elsevier
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