The Hormonal control of gene transcription
Over the past few years there have been considerable advances in our understanding of cellular control mechanisms, and current research is now linking areas of biology that were previously thought of as being quite separate. Molecular Aspects of Cellular Regulation is a series of occasional books on...
| Other Authors: | Cohen, P. 1945-, Foulkes, J. Gordon., ScienceDirect (Online service) |
|---|---|
| Format: | eBook |
| Language: | English |
| Published: |
Amsterdam ; New York :
Elsevier,
1991.
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| Physical Description: |
1 online resource (xxiv, 492 pages) : illustrations. |
| Series: |
Molecular aspects of cellular regulation ;
v. 6. |
| Subjects: |
Table of Contents:
- Front Cover; The Hormonal Control of Gene Transcription; Copyright Page; Editor's foreword; List of contributors; Table of Contents; Section I: Introduction; Chapter 1. An overview of transcription; 1. Introduction; 2. Anatomy of the transcription unit; 3. The structure and function of RNA polymerase II; 4. RNA polymerase II transcription initiation; 5. Transcription termination by RNA polymerase II; 6. Concluding remarks; References; Chapter 2. Regulation of eukaryotic RNA polymerase II transcription by sequence-specific DNA-binding proteins; 1. Introduction.
- 2. Bipartite and universal activation3. Activators as developmental regulators; 4. The different modules for DNA binding and activation; 5. Enhancer organization: the SV40 enhancer; 6. Levels of synergism between enhancer-bound transcription factors; 7. Mechanism of enhancer function; 8. Differential transcriptional activation by Oct-1 and Oct-2: two proteins that bind to the same DNA sequence; 9. Conclusions and perspectives; Acknowledgements; References; Chapter 3. Hormonal effects on gene suppression mediated through transacting factors and chromatin structure; 1. Introduction.
- 2. Chromatin structure and suppression of transcription3. Gene suppression mediated by trans-acting factors; 4. Suppression of gene transcription by steroid hormone receptors; 5. Viral factors may mimic host cell suppressors; 6. Gene suppression by transcriptional termination and blocked RNA elongation; 7. Conclusions; References; Chapter 4. An overview of signal transduction; 1. Introduction; 2. Cell surface receptors; 3. Second messenger generation; 4. Second messenger receptors; 5. Non-linear signal transduction; References.
- Section II: Regulation by hormone receptor-DNA-binding proteins: the steroid superfamilyChapter 5. Mechanisms of regulation of gene transcription by steroid receptors; 1. Introduction; 2. Structure of the steroid receptor; 3. A model for steroid hormone regulation of target genes; 4. Conversion of steroid receptors from the 8-10S complex to the 4-5S complex; 5. Receptor-DNA interactions; 6. Role of steroid hormone receptor in the induction of target gene transcription; 7. The role of hormone in receptor function; 8. Synergistic interaction of steroid response elements.
- 9. Conclusions and perspectiveReferences; Chapter 6. Regulation of transcription by glucocorticoids; 1. Introduction; 2. Positive regulation of transcription: the mouse mammary tumor virus (MMTV) promoter; 3. Negative regulation of transcription by glucocorticoid hormones; 4. Conclusions; Acknowledgements; References; Chapter 7. Regulation of gene transcription by thyroid hormones and retinoic acid; 1. Introduction; 2. Regulation of gene transcription by thyroid hormones; 3. Regulation of gene transcription by the retinoic acid receptor; 4. Summary and future directions; References.