Age of onset of mental disorders etiopathogenetic and treatment implications /
This book presents a thorough and critical review of current knowledge about the age of onset of mental disorders. The opening chapters offer information about the impact of the age of onset on the clinical picture, course, and outcome of physical illnesses, and about the neurobiological implication...
| Other Authors: | De Girolamo, Giovanni,, McGorry, Patrick D.,, Sartorius, N.,, SpringerLink (Online service) |
|---|---|
| Format: | eBook |
| Language: | English |
| Published: |
Cham, Switzerland :
Springer,
[2019]
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| Physical Description: |
1 online resource (xvi, 261 pages) : illustrations. |
| Subjects: |
Table of Contents:
- Intro; Foreword; Contents; Contributors; 1: Introduction: Relevance of the Age of Onset of Mental Disorders to Research in Psychiatry and to the Organization of Services for People with Mental Illness; 1.1 Introduction; 1.2 Age, Development and Diseases; 1.3 Options for the Definition of the Age of Onset: Their Advantages and Disadvantages; 1.3.1 Criterion 1: The Age When the First Morpho-functional Pathological Processes, Which Lead to a Disorder (e.g. Cellular, Receptor or Genetic Alterations or Changes), Appear.
- 1.3.2 Criterion 2: The Age When the First Signs of a Disorder Appear (e.g. Cognitive Dysfunctions)1.3.3 Criterion 3: The Age When the First Symptoms of a Disorder Appear (e.g. Depressed Mood); 1.3.4 Criterion 4: The Age When the First Overt Episode of a Disorder Appears (e.g. First Psychotic Episode); 1.3.5 Criterion 5: The Age of the First Contact with Any Health Service; 1.3.6 Criterion 6: The Age of the First Pharmacological Treatment; 1.3.7 Criterion 7: The Age of the First Hospitalization; 1.4 Methods for Assessing the Age of Onset, Their Advantages and Shortcomings.
- 1.5 Clinical Consequences of Different AOO1.6 Public Health Consequences of Different AOO; 1.7 Plan of the Book; References; 2: Lessons from Knowledge on the Correlates of the Age of Onset of Physical Illness; 2.1 Models of Environmental Influences; 2.1.1 Cumulative Exposure Model: The Example of Lung Cancer and Smoking; 2.1.2 Susceptibility Windows: Breast Cancer and Relevance of Exposure at Puberty; 2.1.3 Developmental Origin of Health and Disease Hypothesis (DOHAD): The Case of Early Socioeconomic Status and Diabetes; 2.1.3.1 Examples from Recent Research.
- 2.1.4 Epigenetic Age Acceleration2.1.4.1 Association of Age Acceleration with Unhealthy Lifestyle and Ageing-Related Diseases; 2.1.4.2 Epigenetic Clock in Newborns and Children; 2.1.4.3 Reversibility of the Effect; References; 3: Does the Age of Onset Shape the Clinical Picture, Course and Consequences of Schizophrenia? Results from a Long-Term Epidemiological Study; 3.1 Introduction; 3.2 Age of Onset (AOO) as a Disorder Marker; 3.3 Early- and Late-Onset Schizophrenia: Are They the Same Disorder?; 3.4 The ABC Study; 3.5 Childhood- and Early-Onset Schizophrenia.
- 3.6 Sex Difference in AOO of Schizophrenia3.6.1 Search for the Causes of Sex Difference in the AOO of Schizophrenia; 3.7 AOO and the Clinical Picture of Schizophrenia; 3.8 AOO and Other Variables Shaping the Course of Schizophrenia; 3.8.1 Clinical and Social Aspects of Late- and Very-Late-Onset Schizophrenia; References; 4: The Age of Onset of Schizophrenia Spectrum Disorders; 4.1 Introduction; 4.2 Incidence by Age and Sex; 4.3 Risk Factors for Early Onset; 4.3.1 Genetic Influence and Family History; 4.3.2 Early Risk Factors; 4.3.3 Premorbid Factors.