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07158cam a2201249 i 4500 |
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1047959887 |
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|a Alvarez-Buylla, Elena,
|e author.
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1 |
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|a Modeling methods for medical systems biology :
|b regulatory dynamics underlying the emergence of disease processes /
|c María Elena Álvarez-Buylla Roces, Juan Carlos Martínez-García, José Dávila-Velderrain, Elisa Domínguez-Hüttinger, Mariana Esther Martínez-Sánchez.
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| 264 |
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|a Cham, Switzerland :
|b Springer,
|c [2018]
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| 264 |
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|c ©2018.
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| 300 |
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|a 1 online resource (xxi, 258 pages) :
|b color illustrations.
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| 336 |
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|a text
|b txt
|2 rdacontent.
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| 337 |
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|a computer
|b c
|2 rdamedia.
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| 338 |
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|a online resource
|b cr
|2 rdacarrier.
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| 490 |
1 |
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|a Advances in experimental medicine and biology,
|x 2214-8019 ;
|v volume 1069.
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| 504 |
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|a Includes bibliographical references and index.
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| 505 |
0 |
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|a Medical systems biology / María Elena Álvarez-Buylla Roces, Juan Carlos Martínez-García, José Dávila-Velderrain, Elisa Domínguez-Hüttinger, Mariana Esther Martínez-Sánchez -- Modeling procedures / María Elena Álvarez-Buylla Roces, Juan Carlos Martínez-García, José Dávila-Velderrain, Elisa Domínguez-Hüttinger, Mariana Esther Martínez-Sánchez -- Case studies / María Elena Álvarez-Buylla Roces, Juan Carlos Martínez-García, José Dávila-Velderrain, Elisa Domínguez-Hüttinger, Mariana Esther Martínez-Sánchez.
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| 520 |
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|a "This book contributes to better understand how lifestyle modulations can effectively halt the emergence and progression of human diseases. The book will allow the reader to gain a better understanding of the mechanisms by which the environment interferes with the bio-molecular regulatory processes underlying the emergence and progression of complex diseases, such as cancer. Focusing on key and early cellular bio-molecular events giving rise to the emergence of degenerative chronic disease, it builds on previous experience on the development of multi-cellular organisms, to propose a mathematical and computer based framework that allows the reader to analyze the complex interplay between bio-molecular processes and the (micro)-environment from an integrative, mechanistic, quantitative and dynamical perspective. Taking the wealth of empirical evidence that exists it will show how to build and analyze models of core regulatory networks involved in the emergence and progression of chronic degenerative diseases, using a bottom-up approach"--Publisher's description.
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| 588 |
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|a Online resource; title from electronic title page (SpringerLink, viewed August 7, 2018).
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| 650 |
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|a Biological models.
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| 650 |
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|a Systems biology.
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| 650 |
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0 |
|a Gene regulatory networks
|x Physiology.
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| 650 |
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0 |
|a Cell physiology.
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| 650 |
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0 |
|a Chronic diseases.
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| 650 |
|
0 |
|a Morphogenesis.
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| 650 |
1 |
2 |
|a Gene Regulatory Networks
|x physiology.
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| 650 |
1 |
2 |
|a Cellular Microenvironment.
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| 650 |
2 |
2 |
|a Cell Physiological Phenomena.
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| 650 |
2 |
2 |
|a Chronic Disease.
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| 650 |
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2 |
|a Morphogenesis.
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| 650 |
2 |
2 |
|a Models, Biological.
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| 650 |
2 |
2 |
|a Systems Biology.
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| 650 |
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6 |
|a Modèles biologiques.
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| 650 |
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6 |
|a Biologie systémique.
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| 650 |
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6 |
|a Réseaux de régulation génique
|x Physiologie.
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| 650 |
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6 |
|a Cellules
|x Physiologie.
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| 650 |
|
6 |
|a Maladies chroniques.
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| 650 |
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6 |
|a Morphogenèse.
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| 650 |
|
7 |
|a Microbiology (non-medical)
|2 bicssc.
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| 650 |
|
7 |
|a Mathematical modelling.
|2 bicssc.
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| 650 |
|
7 |
|a Life sciences: general issues.
|2 bicssc.
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| 650 |
|
7 |
|a NATURE
|x Reference.
|2 bisacsh.
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| 650 |
|
7 |
|a SCIENCE
|x Life Sciences
|x Biology.
|2 bisacsh.
|
| 650 |
|
7 |
|a SCIENCE
|x Life Sciences
|x General.
|2 bisacsh.
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| 650 |
|
7 |
|a Biological models.
|2 fast.
|
| 650 |
|
7 |
|a Cell physiology.
|2 fast.
|
| 650 |
|
7 |
|a Chronic diseases.
|2 fast.
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| 650 |
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7 |
|a Morphogenesis.
|2 fast.
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| 650 |
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7 |
|a Systems biology.
|2 fast.
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| 655 |
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4 |
|a Internet Resources.
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| 700 |
1 |
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|a Martínez-García, Juan Carlos,
|e author.
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| 700 |
1 |
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|a Dávila-Velderrain, José,
|e author.
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| 700 |
1 |
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|a Domínguez-Hüttinger, Elisa,
|e author.
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| 700 |
1 |
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|a Martínez-Sánchez, Mariana Esther,
|e author.
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| 710 |
2 |
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|a SpringerLink (Online service)
|
| 776 |
0 |
8 |
|i Print version:
|a Alvarez-Buylla, Elena.
|t Modeling methods for medical systems biology.
|d Cham, Switzerland : Springer, [2018]
|z 331989353X
|z 9783319893532
|w (OCoLC)1028165608.
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|a Advances in experimental medicine and biology ;
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