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05477cam a2200709Ii 4500 |
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1039079230 |
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OCoLC |
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20180928111935.8 |
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m o d |
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cr cnu|||unuuu |
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180607s2018 ne a ob 001 0 eng d |
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|a 1039674533
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|a 9780128112939
|q (electronic bk.)
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|a 012811293X
|q (electronic bk.)
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|z 9780128112922
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|z 0128112921
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|a (OCoLC)1039079230
|z (OCoLC)1039674533
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|a N$T
|b eng
|e rda
|e pn
|c N$T
|d N$T
|d OPELS
|d YDX
|d EBLCP
|d MERER
|d OCLCF
|d COO
|d OCLCQ
|d OTZ
|d NLE
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|a SCI
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|2 bisacsh
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|a 541/.395
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|a Palladium-catalyzed modification of nucleosides, nucleotides and oligonucleotides /
|c edited by Anant R. Kapdi, Debabrata Maiti, Yogesh S. Sanghvi.
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| 264 |
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1 |
|a Amsterdam, Netherlands :
|b Elsevier,
|c [2018]
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| 300 |
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|a 1 online resource :
|b illustrations.
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| 336 |
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|a text
|b txt
|2 rdacontent.
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| 337 |
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|a computer
|b c
|2 rdamedia.
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| 338 |
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|a online resource
|b cr
|2 rdacarrier.
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| 490 |
1 |
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|a Latest trends in palladium chemistry.
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| 504 |
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|a Includes bibliographical references and index.
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| 588 |
0 |
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|a Online resource; title from PDF title page (EBSCO, viewed June 11, 2018).
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|a Front Cover; Palladium-Catalyzed Modification of Nucleosides, Nucleotides and Oligonucleotides; Copyright; Contents; Contributors; Chapter 1: The Future of Drug Discovery: The Importance of Modified Nucleosides, Nucleotides, and Oligonucleotides; 1. Introduction; 2. Biologically Active Modified Nucleosides; 3. Synthetic Fluorescent Nucleoside Analogs; 4. Oligonucleotide Applications; 5. An Overview of Other Cross-Coupling Reactions in This Book; 6. Stille Cross-Coupling; 7. Suzuki-Miyaura Cross-Coupling; 8. Sonogashira reactions; 9. Heck Cross-Coupling.
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| 505 |
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|a 10. Buchwald-Hartwig reactions11. C-H Activation Reactions; 12. Cross-Coupling of Nucleotides and Oligonucleotides; 13. Summary and Future Directions; References; Chapter 2: Stille Cross-Coupling Reaction: Early Years to the Current State of the Art; 1 Introduction; 2. Stille Coupling Reactions; 2.1 Early Developments; 3 Conclusion; References; Chapter 3: Suzuki-Miyaura Cross-Coupling as a Synthetic Tool for Nucleoside and Nucleotide Modification; 1. Introduction; 2. Suzuki-Miyaura Reaction: Mechanism and Conditions; 2.1 Overview of the Reaction.
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| 505 |
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|a 2.2 Suzuki-Miyaura Reaction in Various Water-Based Catalytic Systems2.2.1 In Tetrahydrofuran/Methanol/Water; 2.2.2 In Dimethylether/Water; 2.2.3 In DMF/H2O; 2.2.4 In ACN/H2O; 2.2.5 In MeOH/H2O; 2.2.6 In H2O; 3. Palladium-Catalyzed Suzuki-Miyaura Routes to Modified Nucleosides; 3.1 Purine Nucleoside Analogues; 3.1.1 Modified Nucleosides at Purine Moiety; 3.1.2 Modified Flexible Nucleosides; 3.1.3 Carbocyclic Nucleosides Analogues; 3.2 Pyrimidine-Modified Analogues; 3.2.1 Arylation at C5- and C6- of Uridine/Cytidine Moiety.
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|a 3.2.2 Arylation of C5-Halo Uridine/Cytidine and C7-Halo Purine Nucleotides3.3 Miscellaneous; 4. Concluding Remarks; Acknowledgments; References; Chapter 4: Sonogashira Cross-Coupling: Alkyne-Modified Nucleosides and Their Applications; 1. Introduction; 2. General Reaction and the Mechanism of Classical Sonogashira Reaction; 3. Modifications of Sonogashira Coupling; 3.1 Modifications of Ligated Pd-Catalysts; 3.2 Generation of Ligand-Free Palladium Catalysts; 3.3 Palladium Nanoparticles as Catalysts.
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| 505 |
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|a 3.4 Modified Form of Cu(I)-Co-Catalyst: Click Reagent Version of Sonogashira Coupling: Contribution From Our Group3.5 Cu-Free Sonogashira Coupling; 3.6 Ligand, Copper, and Amine-Free Palladium Catalyzed Sonogashira Coupling; 4. Applications of the Sonogashira Reaction; 5. Sonogashira Reaction in the Synthesis of Nucleoside; 6. Application of Sonogashira Coupling to Pyrimidine Nucleosides; 6.1 Synthesis of C-4-Substituted Pyrimidines; 6.2 Synthesis of C-5-Substituted Pyrimidines; 7. Sonogashira Coupling for the Synthesis of Substituted Purine Nucleosides.
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| 650 |
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|a Palladium catalysts.
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| 650 |
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|a Nucleosides.
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| 650 |
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|a Nucleotides.
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| 650 |
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|a Oligonucleotides.
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| 650 |
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7 |
|a SCIENCE / Chemistry / Physical & Theoretical.
|2 bisacsh.
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| 650 |
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7 |
|a Nucleosides.
|2 fast.
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| 650 |
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7 |
|a Nucleotides.
|2 fast.
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| 650 |
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7 |
|a Oligonucleotides.
|2 fast.
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| 650 |
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7 |
|a Palladium catalysts.
|2 fast.
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| 655 |
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4 |
|a Electronic books.
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| 700 |
1 |
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|a Kapdi, Anant R.,
|e editor.
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| 700 |
1 |
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|a Maiti, Debabrata,
|e editor.
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| 700 |
1 |
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|a Sanghvi, Yogesh S.,
|d 1956-
|e editor.
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| 710 |
2 |
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|a ScienceDirect (Online service)
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| 776 |
0 |
8 |
|c Original
|z 9780128112922
|z 0128112921
|w (OCoLC)1002834729.
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| 830 |
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|a Latest trends in palladium chemistry.
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|a .b58064722
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|a MARCIVE Q3&4 2018
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|a Loaded with m2btab.ltiac in 2019.12
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|a Loaded with m2btab.ltiac in 2019.01
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|a OCLC offline update by CMU and loaded with m2btab.elec in 2018.10
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|u http://ezproxy.coloradomesa.edu/login?url=https://www.sciencedirect.com/science/book/9780128112922
|3 Elsevier
|z Click here for access
|