Milestones in immunology based on collected papers /
| Main Author: | Ribatti, Domenico, 1956- |
|---|---|
| Other Authors: | ScienceDirect (Online service) |
| Format: | eBook |
| Language: | English |
| Published: |
Oxford :
Academic Press, an imprint of Elsevier,
[2017]
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| Physical Description: |
1 online resource : illustrations. |
| Subjects: |
| Item Description: |
Includes bibliographical references. Front Cover; Milestones in Immunology; Copyright Page; Contents; About the Author; Foreword; References; Further Reading; 1 The Contribution of Bruce Glick to the Definition of the Role Played by the Bursa of Fabricius in the Development of the ...; 1.1 Fabricius ab Aquapendente and the Discovery of the Bursa; 1.2 The Bursa of Fabricius Plays a Major Role in the Development of Antibody-Mediated Immunity; 1.3 Bursectomy do not Abrogate the Antibody Response to Cellular Antigens; 1.4 Immunoglobulin Synthesis Regulation; 1.5 Delineation of the Thymic and Bursal Lymphoid Systems in the Chicken. 1.6 Bursa of Fabricius Equivalent in Mammals and Other VertebratesReferences; 2 The Contribution of Robert A. Good and Francis A.P. Miller to the Discovery of the Role of Thymus in Immunity; 2.1 Biographic Notes; 2.2 The Thymus and Its Function; 2.3 The Functional Anatomy of the Human Thymus; 2.4 Studies of the Thymus in the Chick; 2.5 Idiopathic Acquired Agammaglobulinemia Associated With Thymoma; 2.6 The Effects of Neonatally Thymectomy; 2.7 The Restorative Effect of Thymomas or Thymus Grafts on Thymic Function; 2.8 Removal of Either the Thymus or Bursa of Fabricius. 2.9 The Importance of a Functional Thymus in HumanReferences; Further Reading; 3 The Discovery of the Blood-Thymus Barrier; 3.1 The Concept of Barrier Between Blood and Tissues; 3.2 Horseradish Peroxidase as a Marker of Vascular Permeability; 3.3 The Blood-Thymus Barrier; 3.4 The Description of the Blood-Thymus Barrier; 3.5 Further Evidence of the Existence of the Barrier, Controversies and Clinical Relevance; References; Further Reading; 4 Max D. Cooper and the Delineation of Two Lymphoid Lineages in the Adaptive Immune System; 4.1 Biographic Notes. 4.2 The Role of the Bursa of Fabricius and of the Thymus in the Definition of Two Patterns of Lymphocyte Lineages4.3 The Immunoglobulin Isotype Switching; 4.4 Mammalian "Bursa-Equivalent" Organs and the Role of Liver and Bone Marrow in Lymphopoiesis; 4.5 Clinical Correlates; 4.6 Concluding Remarks; References; 5 Edelman's View on the Discovery of Antibodies; 5.1 Biographic Note; 5.2 The Discovery of the Structure of Immune Globulins; 5.3 The Discovery of L-chain Polypeptide in the Urine of Multiple Myeloma Patients; References. 6 From the Discovery of Monoclonal Antibodies to Their Therapeutic Application: An Historical Reappraisal6.1 The Discovery; 6.2 Therapeutic Applications; 6.3 Concluding Remarks; References; 7 Sir Frank Macfarlane Burnet and the Clonal Selection Theory of Antibody Formation; 7.1 Introduction; 7.2 Biographical Note; 7.3 The Instructive Theories of Antibody Production; 7.4 The Selective Theories of Antibody Production; 7.5 The Clonal Selection Theory; 7.6 Evidence Supporting the Theory; 7.7 Concluding Remarks; References; Further Reading. |
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| Physical Description: |
1 online resource : illustrations. |
| Bibliography: |
Includes bibliographical references. |
| ISBN: |
9780128113295 0128113294 |