Toxicology of herbal products
This volume provides a comprehensive overview of the hazards inherent in herbal medicinal products, with systematic coverage of major toxicities. Topics include composition and quality control, toxicokinetics, interactions, safety pharmacology, approaches to studying complex mixtures including metab...
| Other Authors: | Pelkonen, R. O., Duez, Pierre,, Vuorela, Pia Maarit,, Vuorela, Heikki,, SpringerLink (Online service) |
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| Format: | eBook |
| Language: | English |
| Published: |
Cham, Switzerland :
Springer,
2017.
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| Physical Description: |
1 online resource (xvi, 479 pages) : illustrations (some color) |
| Subjects: |
Herbs
-- Toxicology.
|
| Summary: |
This volume provides a comprehensive overview of the hazards inherent in herbal medicinal products, with systematic coverage of major toxicities. Topics include composition and quality control, toxicokinetics, interactions, safety pharmacology, approaches to studying complex mixtures including metabolomics and systems network pharmacology, and long-term toxicity. The volume also discusses various organ toxicities with a special emphasis on basic mechanisms of actions and the multicomponent and multi-target nature of herbal products. It concludes with a look to future challenges and opportunities. With contributions from noted experts, Toxicology of Herbal Products is a necessary resource for physicians, pharmacists, and toxicologists interested in complex plant-derived products. |
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| Item Description: |
Preface; About the Editors; Contents; Contributors; Chapter 1: Toxicity of Herbal Medicines: From Past to Present to Future; Introduction; Herbal Medicines and Human Beings; Definitions; Time Periods in the Toxicity of Herbal Medicines; Scientific Progress and the Development of Subdisciplines; Development of Regulation Related to the Toxicity of Herbal Medicines; Global Diversity and Future Challenges; References; Chapter 2: History and Current Status of Herbal Medicines; History and Current Status of Herbal Medicines and Herbal Medicinal Products. Early Evidence of Use of Herbal Medicine Neanderthal Period; Neolithic Period; Pre-Christian Period; First Century to the Middle Ages; Non-human Use of Herbal Medicine; Herbal Medicine to Pharmaceuticals; Apothecaries: The Foundation of Pharmaceutical Companies; Plants as the Source of Early Pharmaceuticals; Distribution of Medicinal Plant Species; Source of Herbal Material; Wild Harvest; Cultivation; Wild Harvest vs. Cultivation; The Current Position of Herbal Medicine and Traditional Herbal Medicine; Global Use; New and Emerging Uses; Herbal Medicine Industries. Pharmaceutical Companies Phytopharmaceutical Companies; Nutraceutical Companies; References; Chapter 3: Composition and Quality Control of Herbal Medicines; Introduction; Guidelines on Production of Quality Herbal Material and Herbal Medicinal Products; Good Agricultural and Collection Practices (GACP); Good Manufacturing Practices (GMP); Pharmacopoeias and Herbal Medicinal Plants; Herbal Monographs; EU Directive 2004/24/EC; Quality of Herbal Material and Herbal Medicinal Products; Naming of Plants and Herbal Materials; Plant Species; Herbal Products. Factors Affecting the Chemical Composition of an Herbal Preparation Plant Growth and Collection; Drying; Stability During Storage; Specific Processing; Extraction; Relevance of Chemical Adulterations; Herbal Material and Products: Chemical Composition; Classification of Plant Constituents; Unspecific Matrix Constituents; Plant Secondary Metabolites; Therapeutic Relevance; Actives Directly Related to Quality; Actives and Co-effectors Indirectly Related to Quality; The Example of St. John's Wort; Phenolics as Solubilizers; Saponins as Solubilizers. Complexes and Colloidal Dispersions Solubilization by Polar Matrix Constituents; Stabilization; Pharmacokinetic Synergy; Chemometrics for Quality Control of Finished Herbal Medicines; Quality Control by Only One or a Few Constituents; Quality Control by Chemical Fingerprints; Chromatographic Techniques; Spectroscopic and Hyphenated Techniques; Chemometric Methods; Examples for the Chemometric Analysis of Chemical Fingerprints; Future Challenges; Conclusions; References; Chapter 4: Toxicokinetics of Herbal Products. Includes index. This volume provides a comprehensive overview of the hazards inherent in herbal medicinal products, with systematic coverage of major toxicities. Topics include composition and quality control, toxicokinetics, interactions, safety pharmacology, approaches to studying complex mixtures including metabolomics and systems network pharmacology, and long-term toxicity. The volume also discusses various organ toxicities with a special emphasis on basic mechanisms of actions and the multicomponent and multi-target nature of herbal products. It concludes with a look to future challenges and opportunities. With contributions from noted experts, Toxicology of Herbal Products is a necessary resource for physicians, pharmacists, and toxicologists interested in complex plant-derived products. Includes bibliographical references and index. |
| Physical Description: |
1 online resource (xvi, 479 pages) : illustrations (some color) |
| Bibliography: |
Includes bibliographical references and index. |
| ISBN: |
9783319438061 3319438069 3319438042 9783319438047 |