Organogenetic gene networks genetic control of organ formation /
All animals, including humans, derive from a single cell, which possesses all the genetic instructions needed to define how the animal will look like. However, during development, the millions of cells that derive from the zygote will only select part of this genetic information to give rise to the...
| Other Authors: | Castelli-Gair Hombría, James,, Bovolenta, Paola,, SpringerLink (Online service) |
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| Format: | Electronic |
| Language: | English |
| Published: |
Switzerland :
Springer,
[2016]
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| Physical Description: |
1 online resource. |
| Subjects: |
| Summary: |
All animals, including humans, derive from a single cell, which possesses all the genetic instructions needed to define how the animal will look like. However, during development, the millions of cells that derive from the zygote will only select part of this genetic information to give rise to the various organs of the body. The coordination of different cell behaviours during development results in the formation of specialized tissues and organs giving rise to highly adapted animals. This book provides an overview of how this diversification is achieved during organ formation and how it may have evolved. Conserved cellular processes are presented using examples from selected vertebrate and invertebrate species that illustrate how developmental biologists are solving the complex puzzle of organ formation. This volume is aimed to students, researchers and medical doctors alike who want to find a simple but rigorous introduction on how gene networks control organ formation. |
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| Item Description: |
1 Models for Studying Organogenetic Gene Networks in the 21st Century; Abstract; 1.1 A Brief Historical Frame; 1.2 Choosing an Organogenetic Gene Network. Where to Start?; References; 2 Organogenesis of the C. elegans Vulva and Control of Cell Fusion; Abstract; 2.1 Background; 2.1.1 The Vulva of C. elegans as a Genetic Model Organ; 2.1.1.1 Historic Overview of Vulva Research; 2.1.2 Overview of Vulva Development; 2.2 Three Signaling Pathways Involved in the Control of Vulval Development; 2.2.1 Wnt Signaling; 2.2.2 Notch Signaling; 2.2.3 RTK-Ras-ERK. 2.3 Formation and Maintenance of the Vulval Competence Group2.3.1 How Are the P Cells Polarized to Form Epidermal and Neuronal Linages?; 2.3.2 Notch Signaling and the Formation of the Anchor Cell; 2.3.3 Wnt and RTK/Ras/MAPK Signaling Maintain the Competence of the VPCs; 2.3.4 The Molecular Mechanism Involved in the Maintenance of Cell Cycle Quiescence During Late L1 and L2; 2.4 Vulval Cell Proliferation and Differentiation; 2.4.1 Current Understanding of VPC Fate Determination; 2.4.2 VPC Polarization and Longitudinal Divisions. 2.4.3 The Third Division of the VPCs and Differentiation of Adult Vulval Cells2.4.4 VPC Fate Determination Research and Modeling; 2.5 Vulval Morphogenesis; 2.5.1 Formation of the Uterine-Vulval Connection; 2.5.2 Migration of the Vulval Cells Towards the Center of the Developing Vulva, Invagination and Formation of Seven Stacked Vulval Toroids; 2.5.3 Migration, Attachment and Innervation of Muscle Cells; 2.6 Insight into the Evolution of Vulva Development; 2.6.1 Variation in the Size of the Vulval Competence Group; 2.6.2 Reproductive Barriers; 2.6.3 Induction by Wnt Signaling; Acknowledgments. 3.2.7 Programmed Cell Death During Drosophila CNS Development3.3 Drosophila Neuropeptide Neurons; Repertoire and Generation; 3.3.1 Neuropeptide Neurons: Common Properties and Specification Mechanisms Mediated by Dimmed; 3.3.2 Neuropeptide Neurons: Distinct Sub-types; 3.3.3 Specifying Neuropeptide Neurons; FMRFamide and Nplp1; 3.3.4 Specifying Neuropeptide Neurons; Leucokinin; 3.3.5 Specifying Neuropeptide Neurons; Corazonin; 3.3.6 Specifying Neuropeptide Neurons; Crustacean Cardioactive Peptide; 3.3.7 Specifying Neuropeptide Neurons; Capability. Includes index. All animals, including humans, derive from a single cell, which possesses all the genetic instructions needed to define how the animal will look like. However, during development, the millions of cells that derive from the zygote will only select part of this genetic information to give rise to the various organs of the body. The coordination of different cell behaviours during development results in the formation of specialized tissues and organs giving rise to highly adapted animals. This book provides an overview of how this diversification is achieved during organ formation and how it may have evolved. Conserved cellular processes are presented using examples from selected vertebrate and invertebrate species that illustrate how developmental biologists are solving the complex puzzle of organ formation. This volume is aimed to students, researchers and medical doctors alike who want to find a simple but rigorous introduction on how gene networks control organ formation. |
| Physical Description: |
1 online resource. |
| ISBN: |
9783319427676 3319427679 |