Drug discovery in Africa impacts of genomics, natural products, traditional medicines, insights into medicinal chemistry, and technology platforms in pursuit of new drugs /
Drug discovery originating in Africa has the potential to provide significantly improved treatment of endemic diseases such as malaria, tuberculosis and HIV/AIDS. This book critically reviews the current status of drug discovery research and development in Africa, for diseases that are a major threa...
| Other Authors: | Chibale, Kelly., Davies-Coleman, Mike., Masimirembwa, Collen., SpringerLink (Online service) |
|---|---|
| Format: | eBook |
| Language: | English |
| Published: |
Berlin ; New York :
Springer,
©2012.
Berlin ; New York : [2012] |
| Physical Description: |
1 online resource : color portraits. |
| Subjects: |
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| 245 | 0 | 0 | |a Drug discovery in Africa : |b impacts of genomics, natural products, traditional medicines, insights into medicinal chemistry, and technology platforms in pursuit of new drugs / |c Kelly Chibale, Mike Davies-Coleman, Collen Masimirembwa, editors. |
| 260 | |a Berlin ; |a New York : |b Springer, |c ©2012. | ||
| 264 | 1 | |a Berlin ; |a New York : |b Springer, |c [2012] | |
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| 505 | 0 | 0 | |t Overview of Current Drug Discovery Activities in Africa and Their Links to International Efforts to Combat Tropical Infectious Diseases / |r Barthélemy Nyasse -- |t The National Cancer Institute and Natural Product-Based Drug Discovery in Africa / |r John A. Beutler, Gordon M. Cragg and David J. Newman -- |t Tuberculosis Drug Discovery: Target Identification and Validation / |r Digby F. Warner and Valerie Mizrahi -- |t Targeting Conserved Pathways as a Strategy for Novel Drug Development: Disabling the Cellular Stress Response / |r Adrienne L. Edkins and Gregory L. Blatch -- |t Natural Product-Based Drug Discovery in Africa: The Need for Integration into Modern Drug Discovery Paradigms / |r Eric M. Guantai and Kelly Chibale -- |t Searching for Drugs That Target Multiple Receptors for Anthelmintics from African Natural Products / |r Timothy G. Geary and Eliane Ubalijoro -- |t Application of In Silico, In Vitro and In Vivo ADMET/PK Platforms in Drug Discovery / |r Collen Masimirembwa and Roslyn Thelingwani -- |t Marine Bioprospecting in Southern Africa / |r Michael T. Davies-Coleman and Suthananda N. Sunassee -- |t Natural Product-Based Drug Discovery Against Neglected Diseases with Special Reference to African Natural Resources / |r Sami A. Khalid -- |t Now I Heal with Pride--The Application of Screens-to-Nature Technology to Indigenous Knowledge Systems Research in Botswana: Implications for Drug Discovery / |r Kerstin Andrae-Marobela, Aku N. Ntumy, Masego Mokobela, Mthandazo Dube and Angelina Sosome, et al. -- |t Innovative Approaches to Exploiting Traditional Medicines in Malaria / |r Philippe Rasoanaivo and Solofoniaina Razafimahefa -- |t Anticancer Drug Repositioning Against Tropical Diseases: The Example of Methotrexate in the Treatment of Malaria / |r Alexis Nzila and Kelly Chibale -- |t Tackling the Problem of Antimalarial Resistance / |r John Okombo, Leah Mwai and Alexis Nzila -- |t Random and Rational Approaches to HIV Drug Discovery in Africa / |r R. Hewer, F.H. Kriel and J. Coates -- |t Structure-Based Design of Domain-Selective Angiotensin-Converting Enzyme Inhibitors / |r Ross G. Douglas and Edward D. Sturrock -- |t Natural Products and Antimalarial Drugs: Will Africa Provide the Next Major Breakthrough? / |r Ivan Addae-Mensah and Dorcas Osei-Safo -- |t Nanomedicine in the Development of Drugs for Poverty-Related Diseases / |r Rose Hayeshi, Boitumelo Semete, Lonji Kalombo, Lebogang Katata and Yolandy Lemmer, et al. |
| 504 | |a Includes bibliographical references and index. | ||
| 520 | |a Drug discovery originating in Africa has the potential to provide significantly improved treatment of endemic diseases such as malaria, tuberculosis and HIV/AIDS. This book critically reviews the current status of drug discovery research and development in Africa, for diseases that are a major threat to the health of people living in Africa. Compiled by leading African and international experts, this book presents the science and strategies of modern drug discovery. It explores how the use of natural products and traditional medicines can benefit from conventional drug discovery approaches, and proposes solutions to current technological, infrastructural, human resources, and economic challenges, which are presented when attempting to engage in full-scale drug discovery. Topics addressed are varied; from African medicinal plants to marine bioprospecting, pharmacogenetics and the use of nanotechnology. This book brings together for the first time a collection of strategies and techniques that need to be considered when developing drugs in an African setting. It is an unprecedented and truly international effort, highlighting the remarkable effort made so far in the area of drug discovery research by African scientists, and scientists from other parts of the world working on African health problems. | ||
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