TH17 cells in health and disease
"About 25 years ago, Mosmann & Coffman introduced the TH1/TH2 paradigm of T helper cell differentiationo which helped explain many aspects of adaptive immunity from eliminating intracellular versus extracellular pathogens to induction of different types of tissue inflammation. However, TH1/...
| Other Authors: | Jiang, Shuiping, Dr., SpringerLink (Online service) |
|---|---|
| Format: | eBook |
| Language: | English |
| Published: |
New York :
Springer,
©2011.
|
| Physical Description: |
1 online resource (xiv, 536 pages) : illustrations (some color) |
| Subjects: |
| Summary: |
"About 25 years ago, Mosmann & Coffman introduced the TH1/TH2 paradigm of T helper cell differentiationo which helped explain many aspects of adaptive immunity from eliminating intracellular versus extracellular pathogens to induction of different types of tissue inflammation. However, TH1/TH2 paradigm could not adequately explain development of certain inflammatory responses which provided impetus for the discovery of a new subset ot T cells, called TH17 cells. After the discovery of differentiation and transcription factors for TH17 cells, it was clear that TH17 cells represent an independent subset of T cells with specific functions in eliminating certain extracellular pathogens, presumably not adequately handled by TH1 or TH2 cells. The major role of TH17 cells has been described in inducing auto-immune inflammation. The discovery of TH17 cells has expanded the TH1/TH2 paradigm, and the integration of TH17 cells with TH1 and TH2 effector cells is beginning to explain the underlying mechanisms of tissue inflammation in a number of infections and auto-immune disease settings--From Chapter one by Vijay Kuchroo"--Page 4 of cover. |
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| Item Description: |
Includes bibliographical references and index. "About 25 years ago, Mosmann & Coffman introduced the TH1/TH2 paradigm of T helper cell differentiationo which helped explain many aspects of adaptive immunity from eliminating intracellular versus extracellular pathogens to induction of different types of tissue inflammation. However, TH1/TH2 paradigm could not adequately explain development of certain inflammatory responses which provided impetus for the discovery of a new subset ot T cells, called TH17 cells. After the discovery of differentiation and transcription factors for TH17 cells, it was clear that TH17 cells represent an independent subset of T cells with specific functions in eliminating certain extracellular pathogens, presumably not adequately handled by TH1 or TH2 cells. The major role of TH17 cells has been described in inducing auto-immune inflammation. The discovery of TH17 cells has expanded the TH1/TH2 paradigm, and the integration of TH17 cells with TH1 and TH2 effector cells is beginning to explain the underlying mechanisms of tissue inflammation in a number of infections and auto-immune disease settings--From Chapter one by Vijay Kuchroo"--Page 4 of cover. From Th1/Th2 Pardigm to Th17 cells: Le Roi est Mort, Vive le Roi -- Th17 Cytokines: Characteristics, Regulation, Biological Function -- TGF-beta and Th17 cells -- A Pleiotropic Cytokine and Th17 cells -- Apoptosis and Th17 cell Differentiation -- IL-1 and Innate Immunity in the Differentiation of Th17 cells. Negative Regulation of Th17 Differentiation -- Signal Transduction in Th17 cell Differentiation -- Structure and IL-17 Receptor Signaling -- Trafficking Receptors and Migration of Th17 cell Subsets -- Plastic T cells: Recycling Effector Functions -- Human Th17 cells -- Th17 Cytokines in Primary Mucosal Immunity -- Th17 cells and IL-23 in Gut Inflammation -- The Roles of IL17A and IL17F in Mucosal Infection and Allergy -- Th17 cells in Fungal Infections -- IL-17 cells in Organ Transplantation Rejection and Tolerance -- Th17 cells, Proteins Associated with Th17 Polarization, and their Role in Graft versus Host Disease -- Interplay of Pathogenic Th1/Th17 cells and Regulatory T cells in Auto-immune Disease: A tale of Yin and Yang -- The Role of Interleukin-17 in Systemic Lupus Erythematosus -- IL-17 in B cell Biology and Systemic Lupus Erythematosus -- IL-17 and Th17 cells in Human Rheumatoid Arthritis -- The Role of IL-23/Th17 Immune Pathway in the Pathogenesis of Arthritis -- The Roles of IL-22 and its Related Family Members in the Pathogenesis of Psoriasis -- Th17 Pathway in Psoriasis and INflammatory Skin Diseases -- Th17 cells in the Tumor Micro-environment -- IL-17-producing NKT cells in Airway Inflammation -- IL-17-producing T cells in Auto-immune Disease. |
| Physical Description: |
1 online resource (xiv, 536 pages) : illustrations (some color) |
| Bibliography: |
Includes bibliographical references and index. |
| ISBN: |
9781441993717 1441993711 |