Investigative electrocardiography in epidemiological studies and clinical trials

Electrocardiology is a relatively new modality in clinical trials, but electrocardiograms (ECGs) have already become established as a valuable research tool for investigation of morbidity and mortality risk associated with various clinical and subclinical conditions. ECGs have also become a crucial...

Full description

Main Author: Rautaharju, P.
Other Authors: Rautaharju, Farida., SpringerLink (Online service)
Format: eBook
Language: English
Published: London : Springer, ©2007.
London : [2007]
Physical Description: 1 online resource (x, 289 pages) : illustrations (1 color)
Subjects:
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245 1 0 |a Investigative electrocardiography in epidemiological studies and clinical trials /  |c Pentti Rautaharju and Farida Rautaharju. 
260 |a London :  |b Springer,  |c ©2007. 
264 1 |a London :  |b Springer,  |c [2007] 
264 4 |c ©2007. 
300 |a 1 online resource (x, 289 pages) :  |b illustrations (1 color) 
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504 |a Includes bibliographical references and index. 
505 0 |a Cover -- Contents -- Part 1 Investigative Electrocardiography in Epidemiological Studies and Clinical Trials -- Chapter 1 Cardiac Excitation and Repolarization -- Chapter 2 Electrocardiographic Lead Systems -- Chapter 3 Normal and Arrhythmogenic Ionic Channel Mechanism -- Chapter 4A: Heart Rate and Heart Rate Variability -- Chapter 4B: Methodological Considerations in Heart Rate Variability Analysis -- Chapter 5 Supraventricular Dysrhythmias -- Chapter 6A: Ectopic Ventricular Activity -- Chapter 6B: Record Length, Spontaneous Variability and Suppression of Ectopic Ventricular Complex Activity by Drugs -- Chapter 7A: Left Ventricular Hypertrophy -- Chapter 7B: Normal Standards for Cornell Voltage, Cornell Product and Sokolow-Lyon Voltage -- Chapter 8 Prolonged Ventricular Excitation -- Chapter 9A: Old Myocardial Infarction -- Chapter 9B: Attributable Risk -- Chapter 10A: Primary Repolarization Abnormalities -- Chapter 10B: Procedures for Determination of the Spatial QRS/T Angle from Conventional ECG Measurements -- Chapter 11 QT Prolongation and QT Dispersion -- a Critical Evaluation -- Part 2 Normal ECG Standards for Adults by Gender, Age, and Ethnicity -- Section A: ECG Intervals: Tables -- Section B: ECG Wave Amplitudes: Tables -- Section C: ECG Vector Components and Spatial Magnitudes at Normalized Time Scale: Tables -- Section D: ECG Amplitudes at 10 ms Intervals: Tables -- Section E: Repolarization Waveform Vectors: Tables -- Index -- Last Page. 
588 0 |a Print version record. 
520 |a Electrocardiology is a relatively new modality in clinical trials, but electrocardiograms (ECGs) have already become established as a valuable research tool for investigation of morbidity and mortality risk associated with various clinical and subclinical conditions. ECGs have also become a crucial tool when investigating adverse cardiac events associated with administration of new drugs. Investigative Electrocardiography in Epidemiological Studies and Clinical Trials reviews the prevalence and incidence and emphasizes the prognostic implications of common ECG abnormalities in contrasting populations. It provides a comprehensive, penetrating and critical analysis of topics such as QT prolongation in clinical drug trials, left ventricular hypertrophy, myocardial ischemia/infarction and epidemiological consideration of relative risks associated with ECG abnormalities. As such it is an essential tool in epidemiological or clinical research using ECGs and in investigations of possible adverse responses of new pharmacological agents. With emphasis on providing international coverage of the topic, the well-respected authors present key information on ECG procedures, epidemiology, problem areas, mortality and morbidity risk. These topics are of particular interest to electrocardiologists, investigators in active ECG research in medical clinics participating in clinical trials, epidemiologists, cardiologists, pharmaceutical companies and regulatory bodies. 
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650 0 |a Electrocardiography. 
650 0 |a Heart  |x Diseases  |x Epidemiology. 
650 0 |a Clinical trials. 
650 0 |a Electrocardiography  |x Standards  |v Tables. 
650 0 |a Methodology. 
650 0 |a Research. 
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650 0 |a Electrodiagnosis. 
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650 2 |a Epidemiologic Study Characteristics as Topic. 
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650 2 |a Investigative Techniques. 
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