Functional ultrastructure an atlas of tissue biology and pathology /

The period between 1950 and 1980 were the golden It also provides unique insights into how pathological years of transmission electron microscopy and pro- processes affect cell organization. duced a plethora of new information on the structure of This information is vital to current work in which ce...

Full description

Main Author: Pavelka, Margit, 1945-
Other Authors: Roth, Jürgen., SpringerLink (Online service)
Format: eBook
Language: English
Published: New York : Springer Verlag Wien, 2005.
New York : 2005.
Physical Description: 1 online resource (xv, 326 pages) : illustrations.
Edition: 1st ed.
Subjects:
Table of Contents:
  • Cover
  • Foreword
  • Preface
  • Acknowledgements
  • Contributors of Electron Micrographs
  • Table of Contents
  • The Cell
  • Introduction: Structural organisation of a mammalian cell
  • The Nucleus
  • Architecture of the cell nucleus
  • Cytochemical detection of ribonucleoproteins
  • Nuclear lamina
  • Detection of sites of DNA replication and of interphase chromosome domains
  • Nucleolus
  • Changes of the nucleolar architecture
  • Detection of sites of RNA synthesis
  • Nuclear pore complexes
  • Nuclear pore complexes: Structural changes as monitored by time-lapse atomic force microscopy
  • Mitosis and cell division
  • Apoptosis
  • Viral inclusions
  • The Cytoplasm: The Secretory System
  • Secretory pathway of pancreatic acinar cells
  • Ribosomes, rough endoplasmic reticulum
  • Nuclear envelope and rough endoplasmic reticulum
  • Rough endoplasmic reticulum: Site of protein translocation and initiation of protein N-glycosylation
  • Oligosaccharide trimming, reglucosylation, and protein quality control in the rough endoplasmic reticulum
  • Rough endoplasmic reticulum: Storage site of aggregates of misfolded glycoproteins
  • Russell bodies and aggresomes represent different types of protein inclusion bodies
  • Smooth endoplasmic reticulum
  • Proliferation of the smooth endoplasmic reticulum
  • Pre-Golgi intermediates
  • Pre-Golgi intermediates: Oligosaccharide trimming and protein quality control
  • Golgi apparatus: A main crossroads along secretory pathways
  • Protein secretion visualised by immunoelectron microscopy
  • Protein N-glycosylation: Oligosaccharide trimming in the Golgi apparatus and pre-Golgi intermediates
  • Golgi apparatus: Site of maturation of asparagine-linked oligosaccharides
  • Cell-type-related variations in the topography of Golgi apparatus glycosylation reactions
  • Cell-type-related differences in oligosaccharide structure
  • Topography of biosynthesis of serine/threonine-linked oligosaccharides
  • Golgi apparatus and TGN ... Secretion and endocytosis
  • Golgi apparatus, TGN and trans-Golgi-ER
  • Golgi apparatus, TGN and trans-Golgi-ER: Tilt series
  • Brefeldin A-induced disassembly of the Golgi apparatus
  • Brefeldin A-treatment: Tubulation of Golgi apparatus and endosomes
  • Brefeldin A-treatment: Effect on retrograde transport of internalised WGA
  • Brefeldin A-treatment: Transitional ER-elements and pre-Golgi intermediates
  • Heat shock response of the Golgi apparatus
  • Changes of the Golgi apparatus upon ATP-depletion and ATP-replenishment
  • Secretory granules
  • Secretory granule types
  • The Cytoplasm: The Endocytic System
  • Receptor-mediated endocytosis via clathrin-coated vesicles and virus endocytosis
  • Endosomes and endocytic pathways
  • Endocytic trans-Golgi network and retrograde traffic into the Golgi apparatus
  • Tubular pericentriolar endosomes
  • Langerhans cells and Birbeck granules: Antigen presenting dendritic cells of the epidermis
  • Caveolae
  • Fluid phase endocytosis and phagocytosis
  • The Cytoplasm: Lysosomes and Lysosomal Disorders
  • Lysosomes
  • Lysosomes: Localisation of acid phosphatase, LAMP and polylactosamine
  • I-cell disease
  • Gaucher's disease
  • Fabry's disease
  • GM2 gangliosidoses
  • Farber's disease
  • Wolman's disease
  • tidt.