Combinatorial chemistry on solid supports
Themodernbillion-dollardrug-discoveryprocessstronglyreliesonbothhi- throughput synthesis and screening methods. Whereas the latter is based on molecular biological methods, the ef?cient and reliable generation of c- pound collections often makes use of combinatorial chemistry. Discovered in the 1980...
| Other Authors: | Bräse, Stefan., Beck-Sickinger, Annette, 1960-, SpringerLink (Online service) |
|---|---|
| Format: | eBook |
| Language: | English |
| Published: |
Berlin ; New York :
Springer Verlag,
©2007.
Berlin ; New York : [2007] |
| Physical Description: |
1 online resource (x, 360 pages) : illustrations. |
| Series: |
Topics in current chemistry ;
278. |
| Subjects: |
| Summary: |
Themodernbillion-dollardrug-discoveryprocessstronglyreliesonbothhi- throughput synthesis and screening methods. Whereas the latter is based on molecular biological methods, the ef?cient and reliable generation of c- pound collections often makes use of combinatorial chemistry. Discovered in the 1980s, this methodology was explored extensively in the 1990s by groups in academia and in industry. Without any doubt, combinatorial chemistry changed the whole drug-discovery process and found many applications in cropscience and the material sciences. However, since its implementation, solution- and solid-phase techniques have been competing with each other, and although many companies started theircombinatorialchemistryprogramwithsolid-phasetechniques, soluti- phase combinatorial methods have taken over and now account for appro- mately 25% of all combinatorial efforts. The syntheses of complex, non-polymeric structures, discovered in the 1960s by the late Bruce Merri?eld, was largely ignored in the context of solid supports, mainly due to the fact that appropriate synthesis techniques were not available. Since solid-phase chemical methodology strongly differs from traditional solution-phase chemistry, two chapters deal with this topic. The Bräse group (Jung, Wiehn, Bräse) gives an overview of multifunctional linkers, which can beusedforthegenerationofdiversity-orientedcollections, simplybycleavage fromresins. Still in its infancy, solid-phase reactions employ "simple" amide chemistry in most cases due to their high-yielding, reliable protocols. Ljungdahl, Br-?eld, and Kann address solid-phase organometallic chemistry, which is now one ofthe great challenges in reliable solid-phase organicsynthesis. |
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| Item Description: |
Includes bibliographical references and index. Multifunctional linkers for combinatorial solid phase synthesis / N. Jung [and others] -- Solid phase organometallic chemistry / N. Ljungdahl [and others] -- Solid phase chemistry for the directed synthesis of biologically active polyamine analogs, derivatives, and conjugates / F. Hahn and U. Schepers -- Combinatorial solid-phase natural product chemistry / M. Mentel and R. Breinbauer -- Multiple peptide synthesis to identify bioactive hormone structures / M. Haack and A. Beck-Sickinger -- Automated solid phase oligosaccharide synthesis / B. Castagner and P. Seeberger -- Probing biology with small molecule microarrays (SMM) / N. Winssinger [and others]. Themodernbillion-dollardrug-discoveryprocessstronglyreliesonbothhi- throughput synthesis and screening methods. Whereas the latter is based on molecular biological methods, the ef?cient and reliable generation of c- pound collections often makes use of combinatorial chemistry. Discovered in the 1980s, this methodology was explored extensively in the 1990s by groups in academia and in industry. Without any doubt, combinatorial chemistry changed the whole drug-discovery process and found many applications in cropscience and the material sciences. However, since its implementation, solution- and solid-phase techniques have been competing with each other, and although many companies started theircombinatorialchemistryprogramwithsolid-phasetechniques, soluti- phase combinatorial methods have taken over and now account for appro- mately 25% of all combinatorial efforts. The syntheses of complex, non-polymeric structures, discovered in the 1960s by the late Bruce Merri?eld, was largely ignored in the context of solid supports, mainly due to the fact that appropriate synthesis techniques were not available. Since solid-phase chemical methodology strongly differs from traditional solution-phase chemistry, two chapters deal with this topic. The Bräse group (Jung, Wiehn, Bräse) gives an overview of multifunctional linkers, which can beusedforthegenerationofdiversity-orientedcollections, simplybycleavage fromresins. Still in its infancy, solid-phase reactions employ "simple" amide chemistry in most cases due to their high-yielding, reliable protocols. Ljungdahl, Br-?eld, and Kann address solid-phase organometallic chemistry, which is now one ofthe great challenges in reliable solid-phase organicsynthesis. English. |
| Physical Description: |
1 online resource (x, 360 pages) : illustrations. |
| Bibliography: |
Includes bibliographical references and index. |
| ISBN: |
9783540725107 3540725105 3540725091 9783540725091 1280944080 9781280944086 9786610944088 6610944083 |
| ISSN: |
0340-1022 ; |