Understanding cancer from a systems biology point of view from observation to theory and back /
| Main Author: | Kareva, Irina, |
|---|---|
| Other Authors: | ScienceDirect (Online service) |
| Format: | eBook |
| Language: | English |
| Published: |
London, United Kingdom :
Academic Press, an imprint of Elsevier,
2018.
|
| Physical Description: |
1 online resource. |
| Subjects: |
| Item Description: |
Includes index. Front Cover; UNDERSTANDING CANCER FROM A SYSTEMS BIOLOGY POINT OF VIEW; UNDERSTANDING CANCER FROM A SYSTEMS BIOLOGY POINT OF VIEW: From Observation to Theory and Back; Copyright; Dedication; CONTENTS; 1 -- Introduction; A PRIMER ON MATHEMATICAL MODELING: PREDATOR-PREY; ESTIMATING PARAMETERS; 2 -- Tumor Dormancy; INTRODUCTION; MODELING PARAMETRICALLY HETEROGENEOUS POPULATIONS: PARAMETER DISTRIBUTION TECHNIQUE; PARAMETERS AND DISTRIBUTIONS; Choice of Initial Distribution; Parametrically Heterogeneous Malthusian Growth; Parametrically Heterogeneous Logistic Growth. Parametrically Heterogeneous Allee GrowthDistribution of Growth Parameter c; Distribution of Carrying Capacity l; Distribution of Parameter m; PRIMARY DORMANCY, METASTATIC DORMANCY, BOTH OR NEITHER?; GETTING BACK TO THE QUESTION; REFERENCES; 3 -- Cancer Immunoediting: A Process Driven by Metabolic Competition as a Predator-Prey-Shared Resource Type Model; BACKGROUND; MODEL DESCRIPTION; MODEL INVESTIGATION: USING THE MODEL TO ANSWER QUESTIONS; Brief Introduction to Dynamical Regimes; Aerobic and Glycolytic Tumor Cells Can Cooperate to Defeat the Immune System. WE WROTE AND ANALYZED THE MODEL. NOW WHAT?PHARMACOKINETIC AND PHARMACODYNAMIC MODELING; Drug Pharmacokinetics; INCLUDING THE EFFECTS OF VARIOUS IMMUNOTHERAPEUTIC INTERVENTIONS; Increased Immune Stimulation Can Be Sufficient to Control Tumor Size but not to Eliminate It; High Death Rates of Immune Cells Can Promote Tumor Growth; GETTING BACK TO THE QUESTION; REFERENCES; 4 -- Blood Vessel Formation and Pathological Angiogenesis as Mitigated by Competing Angiogenesis Regulators; INTRODUCTION; NORMAL BLOOD VESSEL FORMATION; WHAT HAPPENS IN TUMORS? USING MATHEMATICAL MODELING FOR HYPOTHESIS TESTINGMODEL DESCRIPTION; PARAMETER ESTIMATION; NORMAL BLOOD VESSEL FORMATION; The Effects of Tumor-Induced Inflow of Angiogenesis Regulators; Comparison With Previously Reported Experimental Data; SUMMARY; REFERENCES; 5 -- Angiogenesis Regulators as a Possible Key to Accelerated Growth of Secondary Tumors Following Primary Tumor Res ...; INTRODUCTION; Model Description; SENSITIVITY ANALYSIS; RESULTS; Time to Surgery and Time to Metastases; THERAPEUTIC IMPLICATIONS; REFERENCES; 6 -- Cancer as a Systemic Disease That Requires a Systemic Approach. ORIGINS OF MAXIMUM TOLERATED DOSE PROTOCOL FOR CHEMOTHERAPY ADMINISTRATIONWHAT DO WE NOW KNOW ABOUT MOST SOLID TUMORS?; CANCER AS AN ECOSYSTEM: LESSONS FROM CONSERVATION BIOLOGY; METRONOMIC (MAINTENANCE) CHEMOTHERAPY AS A WAY TO TARGET TUMOR MICROENVIRONMENT; DECREASED ANGIOGENESIS; IMPROVED ANTITUMOR IMMUNITY; DECREASED THERAPEUTIC RESISTANCE; CLINICAL TRIALS; POTENTIAL SYNERGY BETWEEN IMMUNOTHERAPY AND CHEMOTHERAPY; CYTOTOXIC T-LYMPHOCYTE ANTIGEN-4 INHIBITION; PD-1, PD-L1, AND PD-L2 INHIBITION; COMBINATION: METRONOMIC CHEMOTHERAPY AND CHECKPOINT INHIBITORS. |
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| Physical Description: |
1 online resource. |
| ISBN: |
9780128136744 012813674X |