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|a Biomedical applications of functionalized nanomaterials :
|b concepts, development and clinical translation /
|c edited by Bruno Sarmento, José das Neves.
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|a Amsterdam, Netherlands :
|b Elsevier,
|c [2018]
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|a 1 online resource.
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|a Micro & nano technologies series.
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|a Vendor-supplied metadata.
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|a Front Cover; Biomedical Applications of Functionalized Nanomaterials; Biomedical Applications of Functionalized Nanomaterials; Copyright; Contents; List of Contributors; Preface; REFERENCES; 1 -- From the â#x80;#x9C;Magic Bulletâ#x80;#x9D; to Advanced Nanomaterials for Active Targeting in Diagnostics and Therapeutics; 1. PAUL EHRLICH AND THE â#x80;#x9C;MAGIC BULLETâ#x80;#x9D;; 2. PASSIVE VERSUS ACTIVE TARGETING IN CANCER AS MODEL; 2.1 SUGARS; 2.2 TRANSFERRIN AND LACTOFERRIN; 2.3 FOLIC ACID; 2.4 HYALURONIC ACID; 2.5 ANTIBODIES; 2.6 APTAMERS; 3. EMERGING CHALLENGES AND PERSPECTIVES; ACKNOWLEDGMENTS; REFERENCES.
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|a I -- Ligand Selection and Functionalization of Nanomaterials2 -- Conjugation Chemistry Principles and Surface Functionalization of Nanomaterials; 1. CONJUGATION CHEMISTRY IN THE CONTEXT OF BIOMEDICAL NANOMATERIALS; 2. CONJUGATION CHEMISTRY PRINCIPLES; 2.1 AMINE REACTIONS; 2.1.1 Amide Bond Formation: Strategies; 2.1.1.1 Acyl Halides; 2.1.1.2 Acyl Azides; 2.1.1.3 Acylimidazoles; 2.1.1.4 Anhydrides; 2.1.1.5 O-Acylisourea Using Carbodiimides as Coupling Reagents; 2.1.1.6 Active Esters; 2.1.1.7 Staudinger Ligation; 2.1.1.8 Microwave Activation; 2.1.2 Phosphoramidate Formation: Strategies.
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|a 2.2 THIOL REACTIONS2.2.1 Thioether Bond Formation: Addition of Thiols at Multiple Bonds of Unsaturated Compounds; 2.2.2 Disulfide Bridge; 2.3 HYDROXYL REACTIONS; 2.3.1 Ester Bond Formation: Strategies; 2.3.1.1 Acyl Halides, Anhydrides, and O-Acylisoureas via Carbodiimide Coupling; 2.3.1.2 Mitsunobu Coupling; 2.3.2 Carbamate Linkage Formation: Strategies; 2.4 CARBOXYLIC ACID REACTIONS; 2.5 ALDEHYDES AND KETONES REACTIONS; 2.6 ALKENES AND ALKYNES; 2.6.1 Dielsâ#x80;#x93;Alder Cycloaddition; 2.6.2 Click Chemistry; 2.6.2.1 Huisgen 1,3-Dipolar Azideâ#x80;#x93;Alkyne Cycloadditions; 2.7 PHOTOCHEMICAL REACTIONS.
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|a 3. SELF-ASSEMBLED MONOLAYERS AS A POWERFUL TOOL FOR THE DESIGN OFâ#x80;SŪRFACE-ENGINEERED NANOMATERIALS3.1 BIOMOLECULES CONJUGATION ONTO SELF-ASSEMBLED MONOLAYERS VIA COVALENT BINDING; 3.1.1 Maleimide-Terminated Self-Assembled Monolayers; 3.1.2 Alkyne or Azide-Terminated Self-Assembled Monolayersâ#x80;(ā̂#x80;#x9C;Click Chemistryâ#x80;#x9D;); 3.1.3 Carboxylic Acid-Terminated Self-Assembled Monolayers; 3.1.4 Hydroxyl-Terminated Self-Assembled Monolayers; 3.2 BIOMOLECULES CONJUGATION ON SELF-ASSEMBLED MONOLAYERS VIAâ#x80;ĀFFINITY BINDING; 4. CHALLENGES IN (BIO)CONJUGATION; REFERENCES.
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|a 3 -- Phage Display Technology for Selection of Antibody Fragments1. INTRODUCTION; 2. ANTIBODY PHAGE DISPLAY LIBRARIES; 2.1 ANTIBODIES FROM NAÃ#x8F;VE AND IMMUNE PHAGE DISPLAY LIBRARIES; 2.2 ANTIBODIES FROM SYNTHETIC AND SEMISYNTHETIC PHAGE DISPLAY LIBRARIES; 3. SELECTION AND SCREENING OF ANTIBODY PHAGE DISPLAY LIBRARIES; 4. ANTIBODY ENGINEERING; 4.1 AFFINITY MATURATION OF ANTIBODIES; 4.2 HUMANIZATION OF ANTIBODIES; 5. CONCLUSIONS AND FUTURE PERSPECTIVES; REFERENCES; 4 -- Ribosome Display Technology for Selecting Peptide and Protein Ligands; 1. INTRODUCTION.
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|a Biomedical Applications of Functionalized Nanomaterials: Concepts, Development and Clinical Translation presents a concise overview of the most promising nanomaterials functionalized with ligands for biomedical applications. The first section focuses on current strategies for identifying biological targets and screening of ligand to optimize anchoring to nanomaterials, providing the foundation for the remaining parts. Section Two covers specific applications of functionalized nanomaterials in therapy and diagnostics, highlighting current practice and addressing major challenges, in particular, case studies of successfully developed and marketed functionalized nanomaterials. The final section focuses on regulatory issues and clinical translation, providing a legal framework for their use in biomedicine. This book is an important reference source for worldwide drug and medical devices policymakers, biomaterials scientists and regulatory bodies.
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|a Biomedical materials.
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|a Nanostructured materials.
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|a HEALTH & FITNESS / Holism.
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|a HEALTH & FITNESS / Reference.
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|a MEDICAL / Alternative Medicine.
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|a MEDICAL / Atlases.
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|a MEDICAL / Essays.
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|a MEDICAL / Family & General Practice.
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|a MEDICAL / Holistic Medicine.
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|a MEDICAL / Osteopathy.
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|a Biomedical materials.
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|a Nanostructured materials.
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|a Electronic books.
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|a Sarmento, Bruno,
|e editor.
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|a Neves, José das,
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|a ScienceDirect (Online service)
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