Pancreatic cancer with special focus on topical issues and surgical techniques /
This book provides state of the art knowledge on a broad range of clinical issues in pancreatic cancer, covering topics from screening and pathophysiology to surgical treatments. In particular, the focus is on current controversies and on evidence-based surgical techniques. Further aspects considere...
| Other Authors: | Kim, Sun-Whe,, Yamaue, Hiroki,, SpringerLink (Online service) |
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| Format: | eBook |
| Language: | English |
| Published: |
Berlin, Germany :
Springer,
2017.
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| Physical Description: |
1 online resource (xvii, 472 pages) : illustrations (some color) |
| Subjects: |
| Summary: |
This book provides state of the art knowledge on a broad range of clinical issues in pancreatic cancer, covering topics from screening and pathophysiology to surgical treatments. In particular, the focus is on current controversies and on evidence-based surgical techniques. Further aspects considered include the management of precancerous lesions, diagnostic methods, perioperative care and nonsurgical treatment. The description of surgical methods is supported by many helpful illustrations and important technical issues are carefully addressed. Determination of resectability and extent of surgery is also discussed. Based on recent developments in surgical techniques, some surgeons are performing more and more radical operations. It is essential, however, that surgical strategy is based on the best available evidence and surgeons will find that this book offers valuable help in achieving this aim. In addition, it will be a great asset in clinical practice for all who are involved or interested in the management of pancreatic cancer. |
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| Item Description: |
Includes index. Preface; Contents; List of Editors; Contributors; Part I: Pathology and Tumor Biology; 1: Epidemiology; 1.1 Epidemiology of Pancreatic Cancer; 1.1.1 Incidence; 1.1.2 Mortality; 1.1.3 Survival; 1.1.4 Risk Factors; References; 2: Molecular Alterations in Pancreatic Cancer; 2.1 Introduction; 2.2 Genetic Alterations in PDAs; 2.3 KRAS and the Mitogen-ƯActivated Protein Kinase Pathway; 2.4 TP53; 2.5 CDKN2A; 2.6 SMAD4; 2.7 Chromatin Modification Genes; 2.8 DNA Repair-Associated Genes; 2.9 RNA Processing Genes; 2.10 Wnt Pathway Genes. 2.11 Phosphatidylinositol 3-Kinase (PI3K) Pathway Genes2.12 Molecular Mechanism of Development of PDA; 2.13 Genetic Alterations in Intraductal Papillary Mucinous Neoplasms; 2.14 Familial Pancreatic Cancer; 2.15 Implication of Molecular Alterations in Clinical Practice; References; 3: Pathological Classification; 3.1 Ductal Neoplasms; 3.1.1 Invasive Ductal Adenocarcinoma; 3.1.2 Pancreatic Intraepithelial Neoplasia (PanIN); 3.1.3 Other Carcinomas of Ductal Origin; 3.1.4 Intraductal Neoplasms; 3.1.4.1 Intraductal Papillary Mucinous Neoplasms. 3.1.4.2 Intraductal Tubulopapillary Neoplasms3.1.5 Mucinous Cystic Neoplasms; 3.1.6 Serous Cystic Tumors; 3.1.7 Pancreatic Neuroendocrine Tumors; 3.1.8 Acinar Neoplasms; 3.1.9 Solid Pseudopapillary Neoplasm; 3.1.10 Pancreatoblastoma; 3.1.11 Miscellaneous Cystic Pancreatic Lesions; 3.1.12 Pseudotumors; 3.1.13 Mesenchymal Tumors; 3.1.14 Secondary Tumors; References; 4: Controversial Issues in Pathological Diagnosis; References; 5: Operative Specimen Handling and Evaluation of Resection Margins; 5.1 Introduction; 5.2 Specimen Orientation and External Inspection. 5.2.1 Pancreatoduodenectomy Specimens5.2.1.1 Specimen Orientation; 5.2.1.2 External Examination; 5.2.2 Distal Pancreatectomy Specimens; 5.3 Specimen Fixation; 5.3.1 Specimen Handling Prior to Fixation; 5.3.2 Specimen Fixation; 5.4 Inking of the Specimen Surface; 5.5 Specimen Dissection; 5.5.1 Axial Slicing of Pancreatoduodenectomy Specimens; 5.5.2 Advantages of the Axial Slicing Technique; 5.5.3 Dissection of Distal and Total Pancreatectomy Specimens; 5.5.4 Dissection of Extended Pancreatectomy Specimens; 5.6 Macroscopic Examination. 5.6.1 Identification of Anatomical Structures in Pancreatoduodenectomy Specimens5.6.2 Identification of Anatomical Structures in Distal Pancreatectomy Specimens; 5.6.3 Macroscopic Description; 5.7 Photodocumentation; 5.8 Tissue Sampling; 5.8.1 Sampling Technique; 5.8.2 Sampling of Transection Margins; 5.8.3 Sampling from Specimens with Venous or Arterial Resection; 5.8.4 Sampling from Extended Pancreatic Resection Specimens; 5.8.5 Routinely Sampled Tissues; 5.8.6 Block Key; 5.9 Assessment of the Margin Status; 5.9.1 Macroscopic Examination. This book provides state of the art knowledge on a broad range of clinical issues in pancreatic cancer, covering topics from screening and pathophysiology to surgical treatments. In particular, the focus is on current controversies and on evidence-based surgical techniques. Further aspects considered include the management of precancerous lesions, diagnostic methods, perioperative care and nonsurgical treatment. The description of surgical methods is supported by many helpful illustrations and important technical issues are carefully addressed. Determination of resectability and extent of surgery is also discussed. Based on recent developments in surgical techniques, some surgeons are performing more and more radical operations. It is essential, however, that surgical strategy is based on the best available evidence and surgeons will find that this book offers valuable help in achieving this aim. In addition, it will be a great asset in clinical practice for all who are involved or interested in the management of pancreatic cancer. Includes bibliographical references at the end of each chapters and index. |
| Physical Description: |
1 online resource (xvii, 472 pages) : illustrations (some color) |
| Bibliography: |
Includes bibliographical references at the end of each chapters and index. |
| ISBN: |
9783662471814 3662471817 3662471809 9783662471807 |