Disease-modifying targets in neurodegenerative disorders paving the way for disease-modifying therapies /
| Other Authors: | Baekelandt, Veerle,, Lobbestael, Evy,, ScienceDirect (Online service) |
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| Format: | eBook |
| Language: | English |
| Published: |
London :
Academic Press,
[2017]
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| Physical Description: |
1 online resource : illustrations. |
| Subjects: |
| Item Description: |
Includes bibliographical references and index. 880-01 Cover; Title Page; Copyright Page; Contents; List of Contributors; Chapter 1 -- The multitude of therapeutic targets in neurodegenerative proteinopathies; Protein Misfolding and Aggregation; Mechanism of Assembly; Prion-Like Propagation of Protein Assemblies; Propagation Routes of Pathogenic Protein Aggregates; Limiting Steps in the Propagation of Pathogenic Protein Assemblies; Therapeutic Strategies Targeting the Physiological Levels of Aggregation-Prone Proteins Involved in Neurodegeneration. Therapeutic Strategies Targeting the Misfolding and Aggregation of Proteins Involved in NeurodegenerationTherapeutic Strategies Targeting the Accumulation of Misfolded Pathologic Protein Aggregates; Therapeutic Strategies Targeting the Cell-to-Cell Propagation of Pathogenic Protein Aggregates; Therapeutic Strategies Aimed at Restoring the Damage Pathogenic Protein Aggregates Induce; Therapeutic Strategies Targeting Misfolded Pathologic Protein Aggregate-Mediated Neuroinflammation; Limitations of the Different Therapeutic Strategies; Acknowledgments; References. Mechanisms of Neuroinflammation-Mediated NeurodegenerationAlzheimer's Disease; Parkinson's Disease; Amyotrophic Lateral Sclerosis; Huntington's Disease; Frontotemporal Dementia and Lewy Body Dementia; Therapeutic Strategies Targeting Neuroinflammation in Progressive Neurodegenerative Diseases; Future Perspectives; Conclusions; References; Chapter 4A -- Stem cells in neurodegeneration: mind the gap; Introduction; Part I: Stem Cells; Genome Editing of Stem Cells; The Generation of Specific Cell Types; Part II: Stem Cells as Regenerative Therapy; Clinical Translation and Immunology. |
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| Physical Description: |
1 online resource : illustrations. |
| Bibliography: |
Includes bibliographical references and index. |
| ISBN: |
9780128052662 012805266X |