Computational strategies towards improved protein function prophecy of xylanases from thermomyces lanuginosus
Annotation
| Main Author: | Karthik, M. V. K. |
|---|---|
| Other Authors: | Shukla, Pratyoosh., SpringerLink (Online service) |
| Format: | eBook |
| Language: | English |
| Published: |
New York, NY :
Springer,
©2012.
New York, NY : [2012] |
| Physical Description: |
1 online resource : color illustrations. |
| Series: |
SpringerBriefs in systems biology.
|
| Subjects: |
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| 100 | 1 | |a Karthik, M. V. K. | |
| 245 | 1 | 0 | |a Computational strategies towards improved protein function prophecy of xylanases from thermomyces lanuginosus / |c M.V.K. Karthik, Pratyoosh Shukla. |
| 260 | |a New York, NY : |b Springer, |c ©2012. | ||
| 264 | 1 | |a New York, NY : |b Springer, |c [2012] | |
| 264 | 4 | |c ©2012. | |
| 300 | |a 1 online resource : |b color illustrations. | ||
| 336 | |a text |b txt |2 rdacontent. | ||
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| 347 | |a text file |2 rdaft. | ||
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| 490 | 1 | |a SpringerBriefs in systems biology, |x 2193-4746. | |
| 504 | |a Includes bibliographical references. | ||
| 520 | 8 | |a Annotation |b This Brief reports on the interplay of an amino-acid mutation towards substrate which could lead to enhanced effects on mutant. These effects need to be given consideration in the engineering processes of protein stability and further exploration of such learning are required to provide novel indication for selection of an enzymes. There are very few reports showing such stable, energy efficient model towards improved protein function prediction screening in-silico structure based mutagenesis of xylanases from Thermomyces lanuginosus. | |
| 505 | 0 | |a Computational StrategiesTowards Improved Protein Function Prophecy of Xylanases from Thermomyces lanuginosus; Contents; Abstract; 1 Introduction; 1.1 ... Introduction; References; 2 Background; 2.1 ... Protein Structure; 2.1.1 Classification of Protein Structure; 2.1.2 Protein Surface; 2.2 ... Protein -- Protein Interaction; 2.3 ... Protein Binding Site Prediction; 2.3.1 Identification of Protein -- Ligand Binding Site; 2.3.2 Protein -- Protein Binding Site Prediction; 2.3.2.1 Surface Patch-Based Prediction Methods; 2.3.2.2 Machine Learning Prediction Approaches; 2.4 ... Protein -- Protein Docking. | |
| 505 | 8 | |a 2.4.1 Rigid-Body Docking2.4.2 Fast Fourier Transform; 2.4.3 Benchmark for Testing the Docking Algorithms; 2.4.4 Critical Assessment of Predicted Interactions; 2.4.5 Protein Interface Prediction and Protein Docking; 2.5 ... Flexible Docking; 2.5.1 Side-Chain Flexibility; 2.5.2 Backbone Flexibility; 2.5.3 Soft Docking; References; 3 Materials and Methods; 3.1 ... Selection of Sequences, 3D Structures and Multiple Sequence Alignment; 3.2 ... Mutant Generation; 3.3 ... Energy Minimization; 3.4 ... Stereo-Chemical Quality Check and Analysis of Non-Bonded Interactions; 3.5 ... Protein -- Protein Docking; 3.6 ... InterProScan. | |
| 505 | 8 | |a 3.7 ... Identification of Functionally Important Regions of Wild Type viz. Endo-1, 4-beta xylanases3.8 ... 3d2GO Server: From Protein 3D Structure to Gene Ontology Term; References; 4 Results and Discussions; 5 Conclusion; References. | |
| 546 | |a English. | ||
| 650 | 0 | |a Computational biology. | |
| 650 | 0 | |a Xylanases |x Biotechnology. | |
| 650 | 0 | |a Hydrolases. | |
| 650 | 0 | |a Enzymes. | |
| 650 | 0 | |a Ascomycetes. | |
| 650 | 0 | |a Proteins. | |
| 650 | 0 | |a Pharmaceutical technology. | |
| 650 | 0 | |a Glycosidases. | |
| 650 | 2 | |a Investigative Techniques. | |
| 650 | 2 | |a Eukaryota. | |
| 650 | 2 | |a Hydrolases. | |
| 650 | 2 | |a Amino Acids, Peptides, and Proteins. | |
| 650 | 2 | |a Biochemical Phenomena. | |
| 650 | 2 | |a Enzymes. | |
| 650 | 2 | |a Organisms. | |
| 650 | 2 | |a Analytical, Diagnostic and Therapeutic Techniques and Equipment. | |
| 650 | 2 | |a Chemical Phenomena. | |
| 650 | 2 | |a Chemicals and Drugs. | |
| 650 | 2 | |a Enzymes and Coenzymes. | |
| 650 | 2 | |a Phenomena and Processes. | |
| 650 | 2 | |a Ascomycota. | |
| 650 | 2 | |a Fungal Proteins. | |
| 650 | 2 | |a Enzyme Stability. | |
| 650 | 2 | |a Xylosidases. | |
| 650 | 2 | |a Proteins. | |
| 650 | 2 | |a Fungi. | |
| 650 | 2 | |a Protein Stability. | |
| 650 | 2 | |a Technology, Pharmaceutical. | |
| 650 | 2 | |a Glycoside Hydrolases. | |
| 650 | 2 | |a Computational Biology. | |
| 650 | 6 | |a Bio-informatique. | |
| 650 | 6 | |a Xylanases |x Biotechnologie. | |
| 650 | 6 | |a Hydrolases. | |
| 650 | 6 | |a Enzymes. | |
| 650 | 6 | |a Ascomycètes. | |
| 650 | 6 | |a Protéines. | |
| 650 | 6 | |a Champignons. | |
| 650 | 6 | |a Techniques pharmaceutiques. | |
| 650 | 6 | |a Glycosidases. | |
| 650 | 7 | |a enzyme. |2 aat. | |
| 650 | 7 | |a protein. |2 aat. | |
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| 650 | 7 | |a Hydrolases. |2 fast. | |
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| 650 | 7 | |a Enzymes. |2 fast. | |
| 650 | 7 | |a Ascomycetes. |2 fast. | |
| 650 | 7 | |a Computational biology. |2 fast. | |
| 650 | 7 | |a Xylanases |x Biotechnology. |2 fast. | |
| 653 | 4 | |a Life sciences. | |
| 653 | 4 | |a Biochemistry. | |
| 653 | 4 | |a Enzymes. | |
| 653 | 4 | |a Bioinformatics. | |
| 653 | 4 | |a Enzymology. | |
| 653 | 4 | |a Protein Science. | |
| 655 | 4 | |a Internet Resources. | |
| 700 | 1 | |a Shukla, Pratyoosh. | |
| 710 | 2 | |a SpringerLink (Online service) | |
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