Search Results - "X-ray crystallography"

Multifaceted roles of crystallography in modern drug discovery by NATO Advanced Study Institute on Crystallography in Drug Discovery: a Tool Against CBRN Agents Erice, Italy, SpringerLink (Online service)

Contents: “…-Protein-Ligand Interactions as the Basis for Drug Action -- The Protein Data Bank: Overview and Tools for Drug Discovery -- Small Molecule Crystal Structures in Drug Discovery -- Protein Aggregation and its Prediction -- Importance of Protonation States for the Binding of Ligands to Pharmaceutical Targets -- Protein-Protein Interactions: Structures and Druggability -- Achieving High Quality Ligand Chemistry in Protein-Ligand Crystal Structures for Drug Design -- Molecular Obesity, Potency and Other Addictions in Drug Discovery -- Adventures in Small Molecule Fragment Screening by X-ray Crystallography for Drug Discovery -- Structure-Based Drug Design to Perturb Function of a tRNA-Modifying Enzyme by Active Site and Protein-Protein Interface Inhibition -- Molecular Interaction Analysis for Discovery of Drugs Targeting Enzymes and for Resolving Biological Function.…”
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Crystal symmetries : Shubnikov Centennial papers by ScienceDirect (Online service)

Contents: “…THE ROLE OF CRYSTALLOGRAPHIC SYMMETRY IN THE DIRECT METHODS OF X-RAY CRYSTALLOGRAPHY; 1. SUMMARY; 2. OVERVIEW; 3. THE STRUCTURE INVARIANTS; 4. …”
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Energetic materials. Part 1, Decomposition, crystal and molecular properties 1st ed. by ScienceDirect (Online service)

Contents: “…Structure and Density Predictions for Energetic Materials -- Chapter 8. X-ray Crystallography -- Beyond Structure in Energetic Materials -- Chapter 9. …”
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Chemistry of energetic materials by ScienceDirect (Online service)

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Comprehensive biophysics. Volume 9, Simulation and modeling by ScienceDirect (Online service)

Contents: “…X-ray crystallography; NMR Spectroscopy; Electron microscopy; Mass spectrometry; SAXS; Ultrafast spectroscopic techniques; EPR and Other electron spectroscopies; Computation; Fast flow; Other spectroscopy -- UV-Vis, CD, Raman,…”
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Integrative structural biology with hybrid methods by SpringerLink (Online service)

Contents: “…New experimental tools enabling hybrid methods -- Chapter 4.Complementary use of electron cryomicroscopy and X-ray crystallography: Structural studies of actin and actomyosin filaments -- Chapter 5. …”
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Crystallography : an introduction for earth science and other solid state students by Whittaker, E. J. W. (Eric James William), 1921-

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Enzyme catalysis and regulation by Hammes, Gordon G., 1934-

Contents: “…Probes of Enzyme Structure; Introduction; Amino Acid Sequencing; X-Ray Crystallography; Chemical Modification; Optical Spectroscopy; Nuclear Magnetic Resonance; Spin Labels; References; Chapter 3. …”
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Principles of nucleic acid structure Second edition. by Neidle, Stephen, Sanderson, Mark

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Advances in protein molecular and structural biology methods by ScienceDirect (Online service)

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Organosilicon compounds : theory and experiment (synthesis). Volume 1 by ScienceDirect (Online service)

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Advances in protein chemistry and structural biology : STRUCTURAL GENOMICS by ScienceDirect (Online service)

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Fragment-based drug design : tools, practical approaches, and examples 1st ed. by ScienceDirect (Online service)

Contents: “…Designing a diverse high-quality library for crystallography-based FBDD screening -- Preparation of protein samples for NMR structure, function, and small-molecule screening studies -- Key factors for successful generation of protein-fragment structures requirement on protein, crystals, and technology -- Predicting the success of fragment screening by X-ray crystallography -- Fragment screening of stabilized G-protein-coupled receptors using biophysical methods -- Using computational techniques in fragment-based drug discovery -- How to avoid rediscovering the known -- From experimental design to validated hits a comprehensive walk-through of fragment lead identification using surface plasmon resonance -- Practical aspects of NMR-based fragment screening -- Binding site identification and structure determination of protein-ligand complexes by NMR a semiautomated approach -- Protein thermal shifts to identify low molecular weight fragments -- HTS reporter displacement assay for fragment screening and fragment evolution toward leads with optimized binding kinetics, binding selectivity, and thermodynamic signature -- Fragment screening purely with protein crystallography -- Computational approach to de novo discovery of fragment binding for novel protein states -- Lead generation and examples opinion regarding how to follow up hits -- Medicinal chemistry inspired fragment-based drug discovery -- Effective progression of nuclear magnetic resonance-detected fragment hits -- Advancing fragment binders to lead-like compounds using ligand and protein-based NMR spectroscopy -- Electron density guided fragment-based drug design--a lead generation example -- Experiences in fragment-based lead discovery -- Fragment screening of infectious disease targets in a structural genomics environment.…”
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Molecular biology 2nd edition. by Clark, David P.

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Structural and functional characterization of the immunoproteasome by Huber, Eva Maria

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Advances in inorganic chemistry. Volume 32 by ScienceDirect (Online service)

Contents: “…Molecular Structure: X-Ray Crystallography; IV. Molecular Structure: NMR Spectroscopy; V. …”
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ADVANCES IN COMPUTERS VOL 5. by Alt, Franz L.

Contents: “…Computing Problems and Methods in X-Ray Crystallography; 1. Introduction; 2. General Computational Methods; 3. …”
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Handbook of dynein Second edition. by EBSCOhost

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Hydration structures of proteins : atomic details by Nakasako, Masayoshi

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Biophysical techniques in photosynthesis. Volume II by SpringerLink (Online service)

Contents: “…A Gateway to Photosynthetic Structure -- Non-Linear Contrast Mechanisms for Optical Microscopy -- Magnetic Resonance Imaging of Plants: Water Balance and Water Transport in Relation to Photosynthetic Activity -- Structure -- Crystallization Methods of Membrane Proteins: Practical Aspects of Crystallizing Plant Light-Harvesting Complexes -- X-ray Crystallography of Photosynthetic Proteins -- Electron Crystallography in Photosynthesis Research -- X-ray Scattering for Bio-Molecule Structure Characterization -- Mass Spectrometry-Based Methods for Studying Kinetics and Dynamics in Biological Systems -- Optical Spectroscopy -- Femtosecond Time-Resolved Infrared Spectroscopy -- Nonlinear Femtosecond Optical Spectroscopy Techniques in Photosynthesis -- (Sub)-Picosecond Spectral Evolution of Fluorescence Studied with a Synchroscan Streak-Camera System and Target Analysis -- Optical Spectroscopy of Individual Light-Harvesting Complexes -- Magnetic Resonance -- High-Field/High-Frequency Electron Paramagnetic Resonance Involving Single- and Multiple-Transition Schemes -- High-Time Resolution Electron Paramagnetic Resonance Study of Quantum Beat Oscillations Observed in Photosynthetic Reaction Center Proteins -- Distance Measurements in Photosynthetic Reaction Centers by Pulsed EPR -- Spin Labeling of Photosynthetic Systems -- Magic Angle Spinning (MAS) NMR for Structure Determination in Photosynthesis -- Photochemically Induced Dynamic Nuclear Polarization (Photo-CIDNP) Magic-Angle Spinning NMR -- Theory -- Calculations of Electrostatic Energies in Proteins Using Microscopic, Semimicroscopic and Macroscopic Models and Free-Energy Perturbation Approaches -- Theory of Excitation Energy Transfer and Optical Spectra of Photosynthetic Systems -- Molecular Dynamics Methods for Bioelectronic Systems in Photosynthesis -- Equilibrium and Dynamical Path Integral Methods in Bacterial Photosynthesis -- Density Functional Theory and Car-Parrinello Molecular Dynamics Methods.…”
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