Strategies and tactics in organic synthesis Volume 9 /

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A classic in the area of organic synthesis, Strategies and Tactics in Organic Synthesis provides a forum for investigators to discuss their approach to the science and art of organic synthesis. Rather than a simple presentation of data or a secondhand analysis, we are given stories that vividly demo...

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Bibliographic Details
Corporate Author: ScienceDirect (Online service)
Other Authors: Harmata, Michael, 1959- (Editor)
Format: eBook
Language:English
Published: Amsterdam : Academic Press, 2013.
Edition:First edition.
Physical Description:
1 online resource (xxii, 322 pages)
Subjects:
Organic compounds -- Synthesis.
Online Access:Elsevier - Click here for access
Contents:
  • Machine generated contents note: 1. Total Synthesis of Strychnos Alkaloids Akuammicine, Strychnine, and Leuconicines A and B / Rodrigo B. Andrade
  • 1. Introduction and Overview
  • 2. Background on the Synthesis of Strychnine and Our Retrosynthesis
  • 3. Selected Strategies for Preparing the ABCE Tetracyclic Framework of Strychnos and Aspidosperma Alkaloids
  • 4. Selected Bis-Cyclization Approaches
  • 5. Our Approach to the ABCE Tetracycle
  • 6. Racemic Syntheses of Akuammicine and Strychnine
  • 7. Asymmetric Preparation of the ABCE Tetracycle
  • 8. Asymmetric Syntheses of Leuconicines A and B
  • Acknowledgments
  • References
  • 2. Total Synthesis of the Unusual Peptide Celogentin C / Bing Ma
  • 1. Introduction
  • 2. First Synthetic Plan and Initial Studies
  • 3. Synthesis of the Right-Hand Ring via Oxidative Coupling
  • 4. Early Attempts to Form the Left-Hand Ring
  • 5. Construction of the Left-Hand Ring
  • 6. Oxidative Coupling Is Enabled by an Unexpected Additive
  • 7. Right-Hand Macrolactamization and One Final Surprise
  • 8. Anticancer Screening
  • 9. Conclusion
  • Acknowledgments
  • References
  • 3. The Upside of Panic: Developing a Synthesis of Englerin A / William J. Chain
  • 1. Introduction: Carbonyls and Target Selection
  • 2. Putting the Pieces Together: Developing a Carbonyl-Based Synthesis of Englerin A
  • 3.Completing Englerin A
  • 4. Conclusions, Thoughts, and Future Directions
  • Acknowledgments
  • References
  • 4. Total Synthesis of Anislactone A and (ł)-Merrilactone A / Naim Nazef
  • 1. Introduction
  • 2. First-Generation Synthesis of (ł)-Merrilactone A and (ł)-Anislactone A
  • 3. Conclusions
  • 4. Merrilactone A: Second-Generation Synthesis
  • 5. Conclusions
  • Acknowledgments
  • References
  • 5. Symmetry-Driven Total Synthesis of Merrilactone A and Resolvin E2 / Daisuke Urabe
  • 1.introduction
  • 2. Total Synthesis of Merrilactone A
  • 3. Total Synthesis of Resolvin E2
  • 4. Conclusion
  • Acknowledgments
  • References
  • 6. The Circuitous Journey from Malonamides to BTPhens: Ligands for Separating Actinides from Lanthanides / Laurence M. Harwood
  • 1. Introduction: Partitioning of Minor Actinides and Some Fission Products Within the Nuclear Fuel Cycle
  • 2. Some Fundamental Aspects of the Chemistry of Minor Actinides
  • 3. The Required Properties of the Solvent Extraction Reagents
  • 4. Coextraction of Americium(III) and Europium(III): The "Easy Bit"
  • 5. Selective Separation of Americium(III) from Europium(III) at High Acidity: The "Hard Bit"
  • 6. The Future Prospects
  • Acknowledgments
  • References
  • 7. Total Syntheses of Hamigeran B / Laurence Miesch
  • 1. Introduction
  • 2. Nicolaou's Synthesis
  • 3. Clive and Wang's Syntheses
  • 4. Trost's Synthesis
  • 5. Taber's Synthesis
  • 6. Our Approaches
  • 7. Stoltz's Synthesis
  • 8. Lau's Synthesis
  • 9. Conclusion
  • Acknowledgments
  • References
  • 8. Exploring Prins Strategies for the Synthesis of Okilactomycin / Karl A. Scheidt
  • 1. Introduction
  • 2. Our Synthetic Approach
  • 3. Conclusions
  • Acknowledgments
  • References
  • 9. Taking Risks in Complex Synthesis Design / Jeffrey D. Mighion
  • 1. Introduction
  • 2. Some Examples of Architectural Self-constructions and the Power of Proximity in Complex Synthesis Design
  • 3. Targeting the Truly Fragile: Danishefsky's Synthesis of Disodium Prephenate
  • 4.A Lesson on How to Produce a "Bent Benzene": Baran's Synthesis of Haouamine
  • 5. The Allylic Diazene Rearrangement in a Sophisticated Molecular Context: Schreiber's Synthesis of Dynemicin A-Like Compounds
  • 6. Harnessing the Reactivity of Peroxyl Radicals: Corey's Remarkable Synthesis of Prostaglandin Endoperoxide PGG2 Methyl Ester
  • 7. Concluding Remarks
  • Acknowledgments
  • References
  • 10. Stereoselective Addition of Halogen to Conjugated Enynes and Its Application in the Total Syntnesis of (
  • )-Kumausallene / Weiping Tang
  • 1. Introduction
  • 2. Halogen-Promoted 1,4-Addition to 1,3-Enynes
  • 3. Retrosynthetic Analysis of (
  • )-Kumausallene
  • 4. Stereoselective Synthesis of (
  • )-Kumausallene
  • 5. Conclusion
  • References
  • 11. Total Synthesis of Aspergillide C / Stephen P. Waters
  • 1. Introduction: Identification of the Aspergillides as Synthetic Targets
  • 2. Synthetic Studies on Aspergillide C
  • 3. Waters' Synthesis of (+)-Aspergillide C
  • 4. Conclusions and Future Directions.

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