Statistical applications from clinical trials and personalized medicine to finance and business analytics selected papers from the 2015 ICSA/Graybill Applied Statistics Symposium, Colorado State University, Fort Collins /

The papers in this volume represent a broad, applied swath of advanced contributions to the 2015 ICSA/Graybill Applied Statistics Symposium of the International Chinese Statistical Association, held at Colorado State University in Fort Collins. The contributions cover topics that range from statisti...

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Bibliographic Details
Corporate Authors: International Chinese Statistical Association. Applied Statistics Symposium, SpringerLink (Online service), Graybill Conference
Other Authors: Lin, Jianchang, 1983- (Editor), Wang, Bushi (Editor), Hu, Xiaowen (Editor), Chen, Kun (Researcher in statistics) (Editor), Liu, Ray H. (Editor)
Format: Conference Proceeding eBook
Language:English
Published: Cham, Switzerland : Springer, 2016.
Series:ICSA book series in statistics.
Physical Description:
1 online resource (xv, 359 pages) : illustrations (some color).
Subjects:
Mathematical statistics -- Congresses.
Online Access:SpringerLink - Click here for access

MARC

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245 1 0 |a Statistical applications from clinical trials and personalized medicine to finance and business analytics :  |b selected papers from the 2015 ICSA/Graybill Applied Statistics Symposium, Colorado State University, Fort Collins /  |c Jianchang Lin, Bushi Wang, Xiaowen Hu, Kun Chen, Ray Liu, editors. 
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505 0 |a Preface; Contents; Contributors; Part I Biomarker and Personalized Medicine; Optimal Biomarker-Guided Design for Targeted Therapy with Imperfectly Measured Biomarkers; 1 Introduction; 2 Methods; 2.1 Optimal Allocation Rules; 2.2 Likelihood Ratio Test Based on EM Algorithm; 3 Simulation Studies; 4 Conclusion; Appendix; Proof of Theorem 1; Proof of Theorem 2; References; Statistical Considerations for Evaluating Prognostic Biomarkers: Choosing Optimal Threshold; 1 Introduction; 2 A Brief Review of the ROC Curve; 3 Criteria Based on the ROC Curve; 4 Issues When Reporting the Optimal Threshold. 
505 8 |a 5 Simulation Study; 6 Discussion; References; Accuracy of Meta-Analysis Using Different Levels of Diagnostic Accuracy Measures; 1 Introduction; 2 Methods; 2.1 Definitions of Diagnostic Accuracy Measures; 2.2 A Bivariate Normal Model for Data Generation for Simulation Studies; 2.3 Meta-Analysis for Level 1 Data; 2.4 Meta-Analysis for Level 2 Data; 2.5 Meta-Analysis for Level 3 Data; 2.6 Simulation Experiments; 3 Simulation Results; 4 Discussion; References; Part II Bayesian Methods and Applications; Bayesian Frailty Models for Multi-State Survival Data; 1 Introduction; 2 BMT Data; 3 Models. 
505 8 |a 3.1 Model for Immediate Child States; 3.2 Models for the Gap Times with Path Specific Frailty; 3.3 Likelihood Function; 3.4 Path Probability; 3.5 Relapse Free Probability; 4 Bayesian Inference; 4.1 Prior and Posterior Distributions; 4.2 Bayesian Computations and Model Comparison; 5 Analysis of the BMT Data; 6 Discussion; References; Bayesian Integration of In Vitro Biomarker to Analysis of In Vivo Safety Assessment; 1 Introduction; 2 Methods; 2.1 In Vivo Telemetry Study; 2.2 Statistical Analysis Method; 2.3 The Bayesian Model; 2.4 Posterior Inference; 3 Analysis and Results; 4 Discussion. 
505 8 |a Part III Dose Ranging Studies in Clinical Trials; Sample Size Allocation in a Dose-Ranging Trial Combined with PoC; 1 Background; 2 Number of Doses and Control Groups; 3 Was the Concept Proven?; 4 Comparison of Power; 4.1 Four-Arm Study; 4.2 Five-Arm Study; 5 Discussion; References; Personalized Effective Dose Selection in Dose Ranging Studies; 1 Introduction; 2 Methods; 2.1 Context, Notation and Model; 2.2 Estimation: The INIA Method; 3 Numerical Examples; 3.1 Examples and Evaluation Criteria; 3.2 Single Marker Examples; 3.3 A Two-Marker Example; 3.4 A Multi-Marker Example; 4 Discussion. 
500 |a Includes index. 
588 0 |a Online resource; title from PDF title page (SpringerLink, viewed November 29, 2016). 
520 |a The papers in this volume represent a broad, applied swath of advanced contributions to the 2015 ICSA/Graybill Applied Statistics Symposium of the International Chinese Statistical Association, held at Colorado State University in Fort Collins. The contributions cover topics that range from statistical applications in business and finance to applications in clinical trials and biomarker analysis. Each papers was peer-reviewed by at least two referees and also by an editor. The conference was attended by over 400 participants from academia, industry, and government agencies around the world, including from North America, Asia, and Europe. Focuses on statistical applications from clinical trials, biomarker analysis, and personalized medicine to applications in finance and business analytics A unique selection of papers from broad and multi-disciplinary critical hot topics - from academic, government, and industry perspectives - to appeal to a wide variety of applied research interests All papers feature original, peer-reviewed content. 
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700 1 |a Liu, Ray H.,  |0 https://id.loc.gov/authorities/names/n95034325  |e editor. 
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