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Biomedical applications of inorganic photochemistry
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Corporate Author: | |
---|---|
Other Authors: | , |
Format: | eBook |
Language: | English |
Published: |
[S.l.] :
Academic Press,
2022.
[Place of publication not identified] : 2022. |
Series: | Advances in inorganic chemistry ;
v. 80. |
Physical Description: |
1 online resource. |
Subjects: | |
Online Access: | Elsevier - Click here for access |
Contents:
- Intro
- Biomedical Applications of Inorganic Photochemistry
- Copyright
- Contents
- Contributors
- Preface
- Chapter One: Leveraging the photophysical properties of rhenium(I) tricarbonyl complexes for biomedical applications
- 1. Introduction
- 2. Properties and applications of Re(CO)3 complexes
- 3. Re(CO)3 complexes as photoluminescent imaging agents
- 4. Simple diimine Re(CO)3 complexes exhibit anticancer activity
- 5. Pyridylimine Re(CO)3 complexes
- 6. Isonitrile-containing Re(CO)3 complexes
- 7. Photoactivation of Re(CO)3 anticancer agents.
- 8. Conclusions and future outlook
- Acknowledgments
- References
- Chapter Two: Strategic design of photofunctional transition metal complexes for cancer diagnosis and therapy
- 1. Introduction
- 2. Transition metal complexes for targeted cancer diagnosis and therapy
- 2.1. Glucose transporters
- 2.2. Biotin receptors
- 2.3. Integrins
- 2.4. G-Protein-coupled receptors
- 2.5. Epidermal growth factor receptor
- 2.6. Carbonic anhydrase
- 2.7. Cyclooxygenase
- 2.8. Sialylated glycoproteins and glycolipids
- 3. Activatable transition metal complexes for cancer diagnosis and therapy.
- 3.1. Hypoxia
- 3.2. pH
- 3.3. Polarity
- 3.4. Viscosity
- 3.5. Redox status
- 3.6. Enzymes
- 3.7. Mismatched DNA molecules
- 3.8. Bioorthogonal chemical reporters
- 4. Conclusions and future perspective
- Acknowledgments
- References
- Chapter Three: Advances in the design of photoactivated platinum anticancer complexes
- 1. Introduction
- 2. Discovery of photoactive Pt(IV) anticancer complexes
- 3. Mechanism of action
- 3.1. Radical and ROS generation
- 3.2. DNA as a target
- 3.3. Peptide and protein targets
- 3.4. Induction of immunogenic cell death.
- 4. Axial derivatives of Pt(IV) complexes
- 4.1. Targeting vectors
- 4.2. Multi-action derivatives
- 5. Pt(IV) azide-acetylene derivatives via ̀̀click ́́reactions
- 6. Nanocarriers
- 6.1. Proteins
- 6.2. Polysaccharides
- 6.3. Hydrogels
- 6.4. Block copolymers
- 6.5. Polymetallodrugs
- 6.6. Carbon dots
- 6.7. Up-converting nanoparticles (UCNPs)
- 6.8. Summary and prospects
- Acknowledgments
- References
- Chapter Four: Adventures in the photo-uncaging of small molecule bioregulators
- 1. Introduction
- 2. PhotoNORMs and PhotoCORMs
- 2.1. Uncaging nitric oxide.
- 2.2. Uncaging carbon monoxide
- 3. Enhancing photoreaction SMB release rates with antennas
- 3.1. Organic chromophore antennas
- 3.2. Semiconductor quantum dot antennas
- 4. Moving toward the phototherapeutic window
- 4.1. Single photon excitation strategies
- 4.2. Simultaneous two photon excitation
- 4.3. Upconverting nanoparticles
- 4.4. Nano-carriers
- 5. Biological targeting
- 5.1. Liposomes
- 5.2. Hollow gold nanoshells
- 5.3. Macrophage Trojan Horses
- 6. Summary
- Acknowledgments
- References.