Abeta peptide and Alzheimer's disease celebrating a century of research /

Recent advances in genetics and brain biochemistry point to the Abeta peptide as the major culprit in causing neurodegeneration in Alzheimer's Disease (AD). This title is specifically targeted at summarizing current knowledge of the Abeta peptide and its role in AD. Written by leaders in the in...

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Other Authors: Barrow, Colin J., Small, David H., 1956-, SpringerLink (Online Service)
Format: eBook
Language: English
Published: London : Springer, ©2007.
Physical Description: 1 online resource (xi, 298 pages) : illustrations.
Subjects:
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245 0 0 |a Abeta peptide and Alzheimer's disease :  |b celebrating a century of research /  |c Colin J. Barrow and David H. Small (eds.). 
260 |a London :  |b Springer,  |c ©2007. 
300 |a 1 online resource (xi, 298 pages) :  |b illustrations. 
336 |a text  |b txt  |2 rdacontent. 
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504 |a Includes bibliographical references and indexes. 
505 0 |a Cover -- Contents -- Preface -- Contributors -- 1. A Brief Introduction to the History of the -Amyloid Protein (A) of Alzheimer's Disease -- 2. The Acentric Pathway of Alzheimer's Disease -- 3. The Function of the Amyloid Precursor Protein Family -- 4. The Involvement of A in the Neuroinflammatory Response -- 5. Amyloid -Peptide(1-42), Oxidative Stress, and Alzheimer's Disease -- 6. Amyloid Toxicity, Synaptic Dysfunction, and the Biochemistry of Neurodegeneration in Alzheimer's Disease -- 7. A Variants and Their Impact on Amyloid Formation and Alzheimer's Disease Progression -- 8. Copper Coordination by -Amyloid and the Neuropathology of Alzheimer's Disease -- 9. Cholesterol and Alzheimer's Disease -- 10. Amyloid -Peptide and Central Cholinergic Neurons: Involvement in Normal Brain Function and Alzheimer's Disease Pathology -- 11. Physiologic and Neurotoxic Properties of APeptides -- 12. Impact of -Amyloid on the Tau Pathology in Tau Transgenic Mouse and Tissue Culture Models -- 13. Glial Cells and A Peptides in Alzheimer's Disease Pathogenesis -- 14. The Role of Presenilins in A-Induced Cell Death in Alzheimer's Disease -- 15. Immunotherapeutic Approaches to Alzheimer's Disease -- 16. Mouse Models of Alzheimer's Disease -- Subject Index -- Author Index -- Last Page. 
588 0 |a Print version record. 
520 |a Recent advances in genetics and brain biochemistry point to the Abeta peptide as the major culprit in causing neurodegeneration in Alzheimer's Disease (AD). This title is specifically targeted at summarizing current knowledge of the Abeta peptide and its role in AD. Written by leaders in the industrial and academic world specializing in this rapidly moving area, the book covers fundamental biochemical studies on this peptide, the genetic impact on Abeta expression and processing, and various AD therapeutic strategies that target Abeta. Although specifically focusing on the Abeta peptide and AD. 
546 |a English. 
650 0 |a Amyloid beta-protein. 
650 0 |a Alzheimer's disease  |x Molecular aspects. 
650 0 |a Alzheimer's disease. 
650 1 2 |a Alzheimer Disease  |x etiology. 
650 1 2 |a Alzheimer Disease  |x metabolism. 
650 1 2 |a Amyloid beta-Peptides  |x metabolism. 
650 2 |a Amyloid beta-Peptides. 
650 2 |a Alzheimer Disease. 
650 4 |a Medicine. 
650 6 |a Protéine bêta amyloïde. 
650 6 |a Maladie d'Alzheimer. 
650 6 |a Maladie d'Alzheimer  |x Aspect moléculaire. 
650 7 |a HEALTH & FITNESS  |x Diseases  |x Alzheimer's & Dementia.  |2 bisacsh. 
650 7 |a MEDICAL  |x Neurology.  |2 bisacsh. 
650 0 7 |a Alzheimer's disease  |x Molecular aspects.  |2 cct. 
650 0 7 |a Alzheimer Disease  |x etiology.  |2 cct. 
650 0 7 |a Alzheimer Disease  |x metabolism.  |2 cct. 
650 0 7 |a Amyloid beta-Protein  |x metabolism.  |2 cct. 
650 0 7 |a Amyloid beta-protein.  |2 cct. 
650 7 |a Alzheimer's disease  |2 fast. 
650 7 |a Alzheimer's disease  |x Molecular aspects  |2 fast. 
650 7 |a Amyloid beta-protein  |2 fast. 
653 0 0 |a geneeskunde. 
653 0 0 |a medicine. 
653 0 0 |a volksgezondheid. 
653 0 0 |a public health. 
653 0 0 |a biochemie. 
653 0 0 |a biochemistry. 
653 0 0 |a neurologie. 
653 0 0 |a neurology. 
653 0 0 |a chirurgie. 
653 0 0 |a surgery. 
653 0 0 |a humane genetica. 
653 0 0 |a human genetics. 
653 0 0 |a neurowetenschap. 
653 0 0 |a neuroscience. 
653 1 0 |a Medicine (General) 
653 1 0 |a Geneeskunde (algemeen) 
700 1 |a Barrow, Colin J. 
700 1 |a Small, David H.,  |d 1956-  |1 https://id.oclc.org/worldcat/entity/E39PCjqD7mfTWkQrRygb7gY8hb. 
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776 0 8 |i Print version:  |t Abeta peptide and Alzheimer's disease.  |d London : Springer, ©2007  |z 1852339616  |z 9781852339616  |w (DLC) 2006924588  |w (OCoLC)69022629. 
880 0 |6 505-00/(S  |a A Brief Introduction to the History of the Ý-Amyloid Protein (AÝ) of Alzheimer's Disease / David Small and Colin Barrow -- The AÝcentric Pathway of Alzheimer's Disease / Victor Villemagne, Roberto Cappai, Kevin Barnham, Robert Cherny, Carlos Opazo, Kathy Novakovic, Christopher Rowe and Colin Masters -- The Function of the Amyloid Precursor Protein Family / Roberto Cappai, B. Elise Needham and Giuseppe Ciccotosto -- The Involvement of AÝ in the Neuroinflammatory Response / Piet Eikelenboom, Willem van Gool, Annemieke Rozemuller, Wiep Scheper, Rob Veerhuis and Jeroen Hoozemans -- Amyloid Ý-Peptide(1-42), Oxidative Stress, and Alzheimer's Disease / D. Butterfield -- Amyloid Toxicity, Synaptic Dysfunction, and the Biochemistry of Neurodegeneration in Alzheimer's Disease / Judy Ng, Marie-Isabel Aguilar and David Small -- AÝ Variants and Their Impact on Amyloid Formation and Alzheimer's Disease Progression / Laszlo Otvos -- Copper Coordination by Ý-Amyloid and the Neuropathology of Alzheimer's Disease / Cyril Curtain and Kevin Barnham -- Cholesterol and Alzheimer's Disease / Joanna Cordy and Benjamin Wolozin -- Amyloid Ý-Peptide and Central Cholinergic Neurons: Involvement in Normal Brain Function and Alzheimer's Disease Pathology / Satyabrata Karn, Z. Wei, David MacTavish, Doreen Kabogo, Mee-Sook Song and Jack Jhamandas -- Physiologic and Neurotoxic Properties of AÝ Peptides / Gillian Gregory, Claire Shepherd and Glenda Halliday -- Impact of Ý-Amyloid on the Tau Pathology in Tau Transgenic Mouse and Tissue Culture Models / Jürgen Götz, Della David and Lars Ittner -- Glial Cells and AÝ Peptides in Alzheimer's Disease Pathogenesis / Gilbert Siu, Peter Clifford, Mary Kosciuk, Venkat Venkataraman and Robert Nagele -- The Role of Presenilins in AÝ-Induced Cell Death in Alzheimer's Disease / Maria Ankarcrona -- Immunotherapeutic Approaches to Alzheimer's Disease / Josef Karkos -- Mouse Models of Alzheimer's Disease / Dwight German. 
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