Abeta peptide and Alzheimer's disease celebrating a century of research /
Recent advances in genetics and brain biochemistry point to the Abeta peptide as the major culprit in causing neurodegeneration in Alzheimer's Disease (AD). This title is specifically targeted at summarizing current knowledge of the Abeta peptide and its role in AD. Written by leaders in the in...
| Other Authors: | Barrow, Colin J., Small, David H., 1956-, SpringerLink (Online Service) |
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| Format: | eBook |
| Language: | English |
| Published: |
London :
Springer,
©2007.
|
| Physical Description: |
1 online resource (xi, 298 pages) : illustrations. |
| Subjects: |
| Summary: |
Recent advances in genetics and brain biochemistry point to the Abeta peptide as the major culprit in causing neurodegeneration in Alzheimer's Disease (AD). This title is specifically targeted at summarizing current knowledge of the Abeta peptide and its role in AD. Written by leaders in the industrial and academic world specializing in this rapidly moving area, the book covers fundamental biochemical studies on this peptide, the genetic impact on Abeta expression and processing, and various AD therapeutic strategies that target Abeta. Although specifically focusing on the Abeta peptide and AD. |
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| Item Description: |
Includes bibliographical references and indexes. Cover -- Contents -- Preface -- Contributors -- 1. A Brief Introduction to the History of the -Amyloid Protein (A) of Alzheimer's Disease -- 2. The Acentric Pathway of Alzheimer's Disease -- 3. The Function of the Amyloid Precursor Protein Family -- 4. The Involvement of A in the Neuroinflammatory Response -- 5. Amyloid -Peptide(1-42), Oxidative Stress, and Alzheimer's Disease -- 6. Amyloid Toxicity, Synaptic Dysfunction, and the Biochemistry of Neurodegeneration in Alzheimer's Disease -- 7. A Variants and Their Impact on Amyloid Formation and Alzheimer's Disease Progression -- 8. Copper Coordination by -Amyloid and the Neuropathology of Alzheimer's Disease -- 9. Cholesterol and Alzheimer's Disease -- 10. Amyloid -Peptide and Central Cholinergic Neurons: Involvement in Normal Brain Function and Alzheimer's Disease Pathology -- 11. Physiologic and Neurotoxic Properties of APeptides -- 12. Impact of -Amyloid on the Tau Pathology in Tau Transgenic Mouse and Tissue Culture Models -- 13. Glial Cells and A Peptides in Alzheimer's Disease Pathogenesis -- 14. The Role of Presenilins in A-Induced Cell Death in Alzheimer's Disease -- 15. Immunotherapeutic Approaches to Alzheimer's Disease -- 16. Mouse Models of Alzheimer's Disease -- Subject Index -- Author Index -- Last Page. Recent advances in genetics and brain biochemistry point to the Abeta peptide as the major culprit in causing neurodegeneration in Alzheimer's Disease (AD). This title is specifically targeted at summarizing current knowledge of the Abeta peptide and its role in AD. Written by leaders in the industrial and academic world specializing in this rapidly moving area, the book covers fundamental biochemical studies on this peptide, the genetic impact on Abeta expression and processing, and various AD therapeutic strategies that target Abeta. Although specifically focusing on the Abeta peptide and AD. English. |
| Physical Description: |
1 online resource (xi, 298 pages) : illustrations. |
| Bibliography: |
Includes bibliographical references and indexes. |
| ISBN: |
9781846284403 1846284406 1852339616 9781852339616 6610804753 9786610804757 1280804750 9781280804755 |